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Pulmonary Vascular Resistance in Repaired Congenital Diaphragmatic Hernia vs. Age Matched Controls

Zussman, Matthew E., M.D.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335462514

Abstract Details

2012, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Infants and children with repaired congenital diaphragmatic hernia (CDH) often continue to show delayed growth and development which may be, in part, secondary to unrecognized persistence of increased pulmonary vascular resistance (PVR). Data was reviewed from all patients age 6 to 36 months with repaired CDH who underwent cardiac catheterization from 2007 to 2010 and was compared to data from a control population of patients undergoing percutaneous closure of a patent ductus arteriosus (PDA). Indexed pulmonary blood flow (Qp), mean pulmonary artery pressure (mPAP), pulmonary capillary wedge pressure (PCWP) and PVR were examined. Data from 8 CDH patients and 10 control patients were examined. The mPAP (22.5 ¿¿¿¿ 3.33 vs. 18.2 ¿¿¿¿ 4.13 mmHg) and PVR (3.66 ¿¿¿¿ 0.79 vs. 1.22 ¿¿¿¿ 0.4 iwU (indexed Wood’s units)) were both significantly elevated in the CDH population while the Qp (4.08 ¿¿¿¿ 1.43 vs. 6.82 ¿¿¿¿ 1.46 l/min/m2) was significantly lower in this population. There was no significant difference in PCWP. Under half of the CDH patients had signs of pulmonary hypertension on echocardiogram. Our data suggests that children age 6 to 36 months with repaired CDH have significantly increased PVR compared to controls and early consideration of cardiac catheterization may be warranted.
Erin Nicole Haynes, PhD (Committee Chair)
Russell Hirsch, MD (Committee Member)
Woody Benson, MD PhD (Committee Member)
19 p.
Health Sciences
congenital diaphragmatic hernia; pulmonary hypertension; cardiac catheterization; hemodynamics; ; ;

Recommended Citations

Citations

  • Zussman, M.D., M. E. (2012). Pulmonary Vascular Resistance in Repaired Congenital Diaphragmatic Hernia vs. Age Matched Controls [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335462514

    APA Style (7th edition)

  • Zussman, M.D., Matthew. Pulmonary Vascular Resistance in Repaired Congenital Diaphragmatic Hernia vs. Age Matched Controls. 2012. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335462514.

    MLA Style (8th edition)

  • Zussman, M.D., Matthew. "Pulmonary Vascular Resistance in Repaired Congenital Diaphragmatic Hernia vs. Age Matched Controls." Master's thesis, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1335462514

    Chicago Manual of Style (17th edition)

ucin1335462514
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© 2012, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.