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Live Yeast Cell Derivative leads to rapid phosphorylation of Epidermal Growth Factor Receptor

Meeker, Timothy J.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337888734

Abstract Details

2012, MS, University of Cincinnati, Arts and Sciences: Biological Sciences.
Live Yeast Cell Derivative (LYCD) is a medicinal extract of stressed stationary phase yeast that accelerates wound healing in mice and man. Multiple lines of convergent evidence have supported the central role of the epidermal growth factor receptor (EGFR) in the respiratory and mitogenic effects of LYCD. Consistent with this evidence we proposed that LYCD caused EGFR phosphorylation and this was dependent upon EGF family ligand release from the cell. We found that LYCD enhanced the tyrosine phosphorylation of EGFR by four-fold after two minutes. Furthermore, this phosphorylation enhancement was abrogated both by the EGFR kinase site inhibitor AG1478 and the broad spectrum metalloprotease inhibitor GM6001. These findings support a mechanism whereby EGFR phosphorylation is caused by metalloprotease-mediated cleavage of EGF family ligands.
Daniel Buchholz, PhD (Committee Chair)
Patrick Limbach, PhD (Committee Member)
Charlotte Paquin, PhD (Committee Member)
55 p.
Cellular Biology
Live Yeast Cell Derivative; LYCD; EGFR; tyrosine phosphorylation; transactivation; ;

Recommended Citations

Citations

  • Meeker, T. J. (2012). Live Yeast Cell Derivative leads to rapid phosphorylation of Epidermal Growth Factor Receptor [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337888734

    APA Style (7th edition)

  • Meeker, Timothy. Live Yeast Cell Derivative leads to rapid phosphorylation of Epidermal Growth Factor Receptor. 2012. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337888734.

    MLA Style (8th edition)

  • Meeker, Timothy. "Live Yeast Cell Derivative leads to rapid phosphorylation of Epidermal Growth Factor Receptor." Master's thesis, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1337888734

    Chicago Manual of Style (17th edition)

ucin1337888734
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© 2012, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.