Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


ucin1342544553.pdf (245.64 KB)

ETD Abstract Container

Abstract Header

Association of Glycemia with Cystatin C in Youth with Diabetes

Kanakatti Shankar, Roopa
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544553

Abstract Details

2012, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Abstract Objective: Serum cystatin C (cysC) is proposed as a biomarker of early renal dysfunction and cardiovascular disease in adults with diabetes. Potential factors affecting cysC in youth with diabetes are unknown. We sought to establish the distribution of cysC in youth with diabetes and determine the influence of measures of glycemia on cysC. Hypothesis: CysC will correlate negatively with fasting serum glucose (FSG) and hemoglobinA1c (A1c) in youth with type 1 and type 2 diabetes. Aim 1: Describe the distribution of cysC in youth with type 1 and type 2 diabetes Aim 2: Determine the influence of FSG and A1c on cysC after adjusting for known determinants such as age, gender, race/ethnicity and other cardiovascular risk factors. Methods: The study population consisted of 959 participants in the SEARCH for Diabetes in Youth study with 825 ‘type 1’, 127 ‘type 2’ and 7 ‘other’ diabetes, all of less than 5 years duration. Linear regression models were fitted for type 1 and type 2 diabetes to study the contribution of FSG and A1c to variability in cysC after adjusting for age, gender, race/ethnicity, duration of diabetes, body mass index Z-score, systolic and diastolic blood pressure Z-scores, urine albumin/creatinine ratio, total cholesterol, HDL cholesterol and triglycerides. Results: Serum cysC showed no deviation from normality (mean 0.75mg/L, SD 0.12). In type 1 diabetes, FSG and A1c were significantly negatively associated with cysC. In type 2 diabetes, FSG but not the A1c was significantly negatively associated with cysC. FSG explained 2.7% and 5.3% of variability in the models for type 1 and type 2 diabetes. Conclusions: Acute glycemic control is associated with cysC in both type 1 and type 2 diabetes while chronic glycemic control, measured by A1c is associated with cysC in type 1 but not type 2 diabetes. Glycemic control must be accounted for, in the interpretation of cysC measures in youth with diabetes.
Erin Nicole Haynes, PhD (Committee Chair)
Lawrence M. Dolan, MD (Committee Member)
Jane Khoury, MS PhD (Committee Member)
26 p.
Surgery
Cystatin C; Type 1 diabetes; Type 2 diabetes; Glycemia; ; ;

Recommended Citations

Citations

  • Kanakatti Shankar, R. (2012). Association of Glycemia with Cystatin C in Youth with Diabetes [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544553

    APA Style (7th edition)

  • Kanakatti Shankar, Roopa. Association of Glycemia with Cystatin C in Youth with Diabetes. 2012. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544553.

    MLA Style (8th edition)

  • Kanakatti Shankar, Roopa. "Association of Glycemia with Cystatin C in Youth with Diabetes." Master's thesis, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1342544553

    Chicago Manual of Style (17th edition)

ucin1342544553
240
© 2012, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.