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Development of a System Model for Non-Invasive Quantification of Bilirubin in Jaundice Patients

Alla, Suresh-Kumar
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352490353

Abstract Details

2012, PhD, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
Neonatal jaundice is a medical condition which occurs in newborns as a result of an imbalance between the production and elimination of bilirubin. Excess bilirubin in the blood stream diffuses into the surrounding tissue leading to a yellowing of the skin. An optical system integrated with a signal processing system is used as a platform to noninvasively quantify bilirubin concentration through the measurement of diffuse skin reflectance. Initial studies have lead to the generation of a clinical analytical model for neonatal jaundice which generates spectral reflectance data for jaundiced skin with varying levels of bilirubin concentration in the tissue. The spectral database built using the clinical analytical model is then used as a test database to validate the signal processing system in real time. This evaluation forms the basis for understanding the translation of this research to human trials. The clinical analytical model and signal processing system have been successful validated on three spectral databases. First spectral database is constructed using a porcine model as a surrogate for neonatal skin tissue. Samples of pig skin were soaked in bilirubin solutions of varying concentrations to simulate jaundice skin conditions. The resulting skins samples were analyzed with our skin reflectance systems producing bilirubin concentration values that show a high correlation (R2 = 0.94) to concentration of the bilirubin solution that each porcine tissue sample is soaked in. The second spectral database is the spectral measurements collected on human volunteers to quantify the different chromophores and other physical properties of the tissue such a Hematocrit, Hemoglobin etc. The third spectral database is the spectral data collected at different time periods from the moment a bruise is induced.
Fred Beyette, PhD (Committee Chair)
Joseph Clark, PhD (Committee Member)
Arthur Helmicki, PhD (Committee Member)
Philip Wilsey, PhD (Committee Member)
99 p.
Optics
Noninvasive; diffuse reflectance; Optical spectroscopy; Jaundice;

Recommended Citations

Citations

  • Alla, S.-K. (2012). Development of a System Model for Non-Invasive Quantification of Bilirubin in Jaundice Patients [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352490353

    APA Style (7th edition)

  • Alla, Suresh-Kumar. Development of a System Model for Non-Invasive Quantification of Bilirubin in Jaundice Patients. 2012. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352490353.

    MLA Style (8th edition)

  • Alla, Suresh-Kumar. "Development of a System Model for Non-Invasive Quantification of Bilirubin in Jaundice Patients." Doctoral dissertation, University of Cincinnati, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352490353

    Chicago Manual of Style (17th edition)

ucin1352490353
744
© 2012, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.