Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
3408.pdf (443.08 KB)
ETD Abstract Container
Abstract Header
Systemic Delivery of microRNA as a Therapeutic Modality to Treat Cancer
Author Info
Pozniak, John
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367939186
Abstract Details
Year and Degree
2013, MS, University of Cincinnati, Medicine: Molecular and Developmental Biology.
Abstract
MicroRNAs (miRNA) are small noncoding RNAs with an important role in the initiation and progression of human cancers by posttranscriptional regulation of tumors suppressors and oncogenes. Recent evidence showing miRNAs are aberrantly expressed in tumors underscores them as potential targets for therapeutic intervention. The rationale for developing miRNA-based cancer therapeutics is based on correcting miRNA expression by either antagonism or miRNA replacement in tumors that may provide therapeutic benefit. This article surveys the present knowledge of cancer-associated miRNAs and considers advantages and potential challenges of current delivery technologies employed to systemically deliver miRNAs to tumors by experimental and pre-clinical studies that have used these approaches.
Committee
Daniel Starczynowski, Ph.D. (Committee Chair)
Chunying Du, Ph.D. (Committee Member)
Kathryn Wikenheiser-Brokamp , Ph.D. M.D. (Committee Member)
Pages
17 p.
Subject Headings
Oncology
Keywords
miRNA
;
Cancer
;
AntagomiR
;
Systemic Delivery
;
Mimic
;
Replacement Therapy
;
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Pozniak, J. (2013).
Systemic Delivery of microRNA as a Therapeutic Modality to Treat Cancer
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367939186
APA Style (7th edition)
Pozniak, John.
Systemic Delivery of microRNA as a Therapeutic Modality to Treat Cancer.
2013. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367939186.
MLA Style (8th edition)
Pozniak, John. "Systemic Delivery of microRNA as a Therapeutic Modality to Treat Cancer." Master's thesis, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367939186
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
ucin1367939186
Download Count:
508
Copyright Info
© 2013, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.