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Docosahexaenoic acid status and blood lipids in overweight/obese pregnant women

Gerardo, Rodrigo
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024685

Abstract Details

2013, MS, University of Cincinnati, Allied Health Sciences: Nutrition.
Objective: The objective of this thesis was to investigate whether plasma erythrocyte DHA (EDHA) status was related to blood lipid concentrations measured at the end of the third trimester in healthy, overweight/obese pregnant women. Design: Observational analysis of women grouped by EDHA status. Sample: Pregnant women, 18 -40 years of age, with a BMI = 25 were recruited from the regional areas of Cincinnati, Ohio and San Antonio, Texas. Methods: Pregnant women were categorized by EDHA status determined at the 36th week of pregnancy. EDHA status was divided into two groups based on the reported concentration to achieve DHA equilibrium for the mother and the baby; high status was defined as an EDHA concentration = 6% and low status was <.599%. Fasting venous blood was analyzed total triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), and total cholesterol (TC) concentrations. Each lipid was measured at the 26th gestational week (baseline, study visit 1 {SV1}and the 36th gestational week (study end, study visit 3 {SV3}.. For this analysis, change in the lipid concentrations were defined as the absolute change (mg/dl) or the percentage of change (%) in TG, LDL-c, HDL-c, and TC from baseline to study end. Results: EDHA% was significantly correlated with TG concentrations (r = + 0.338, p=0.001), absolute change in LDL-c (r = +0.238, p = 0.021), TC concentrations (r = +0.262, p = 0.01), and change in TC (r = +0.209, p = 0.045). At SV3, subjects in the high EDHA status group had significantly higher mean TG concentration (low status: 200.65 mg/dL; high status: 245.55 mg/dL; p=0.001) and TC concentration (low status: 214.94 mg/dL; high status: 234.22 mg/dL; p=0.039). Conclusion: EDHA% in overweight/obese pregnant women was significantly, positively correlated with TG concentration, absolute change in LDL-c, TC concentration, and absolute change in TC. Women in the high EDHA status group had significantly higher TG and TC when compared to women in the low EDHA status group. Further research is needed to determine if these observations are related to changes in outcomes for the mother and infant.
Debra Ann Krummel, Ph.D. (Committee Chair)
Graciela Falciglia, Ph.D. (Committee Member)
43 p.
Nutrition
DHA; lipids; pregnancy; obesity;

Recommended Citations

Citations

  • Gerardo, R. (2013). Docosahexaenoic acid status and blood lipids in overweight/obese pregnant women [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024685

    APA Style (7th edition)

  • Gerardo, Rodrigo. Docosahexaenoic acid status and blood lipids in overweight/obese pregnant women. 2013. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024685.

    MLA Style (8th edition)

  • Gerardo, Rodrigo. "Docosahexaenoic acid status and blood lipids in overweight/obese pregnant women." Master's thesis, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368024685

    Chicago Manual of Style (17th edition)

ucin1368024685
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© 2013, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.