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Validation of the Health-Related Productivity Questionnaire and U.S. Population Norms

Tundia, Namita

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, PhD, University of Cincinnati, Pharmacy: Pharmaceutical Sciences/Biopharmaceutics.
Objectives: The purpose of this dissertation was to i) validate a new health-related productivity instrument (HRPI) called the Health-Related Productivity Questionnaire (HRPQ), ii) estimate the U.S. population norms for HRPQ by age, gender and employment status and iii) measure lost productivity in women with endometriosis. Methods: An online survey was constructed that consisted of four components: the HRPQ; a screener to determine relevant disease conditions-related and health-state questions socio-demographic questions; a validated health-related productivity instrument, Work Productivity and Activity Impairment (WPAI); and a Quality of Life instrument, EurolQol-5 Dimension (EQ-5D). The survey was administered by a third-party company in three rounds. At the end of third round of data collection, we had responses from 10,011 participants. Participants who completed the survey were systematically randomly selected such that the resulting sample represented the United States general population. Validation analysis of the HRPQ included concurrent and criterion-related validity; construct validity with group difference analysis, extreme group comparison and confirmatory factor analysis. Weighted mean, median, standard error, 25th and 75th percentiles were calculated for absenteeism, presenteeism measures for paid and unpaid work activities, stratified by age, gender, age and gender, employment status and selected broad disease conditions. Women who self-reported as have ever been diagnosed with endometriosis were identified and two sub-groups were created: i) larger sample of women of age =18 years; ii) a smaller sample of women of age 18 to 49 years. Larger sample was used to measure loss of workforce participation and smaller sample was used to compare differences in lost productivity measures between women with and without symptoms. Results: HRPQ showed strong concurrent validity with WPAI with a Pearson&#x2019;s correlation of r =0.6 (p-value<0.05) for several lost productivity measures. Correlation of paid and unpaid work productivity from HRPQ with EQ-5D index score and Visual Analogue Scale, were small to moderate, r=0.3-0.5 (p-value<0.05) and aligned with direction of the hypothesis. Several group difference analyses showed positive results for HRPQ. In general population, younger age-group 18-29 years old in both males (19.5%) and females (20.0%) had significantly highest (p-value<0.05) productivity loss at work than all other age-groups, mostly due to presenteeism (males:14.7%, females:12.2%) than absenteeism (males:4.9%, females:7.8%). Furthermore, lost productivity at work was significantly differences between males (8.6%) and females (13.4%) in age-group of 50 to 64 years old. For household-related activities, lost productivity was highest (p-value<0.05) in 30 to 39 years old among all age-groups, in both males (30.7%) and females (35.2%) with significantly higher loss (p-value<0.05) in females than males. In women with endometriosis, significant differences (p-value<0.05) between women with and without symptoms were observed for average overall productivity (45% and 16%, respectively) and average absenteeism (31% and 3%, respectively). Conclusions: HRPQ has good construct and criterion validity. In general population, females have higher lost productivity than males and health-related lost productivity decreases with increase in age. Presenteeism remains higher for paid work, while absenteeism remains higher for unpaid work. In women with endometriosis, symptoms can have significant impact on paid and unpaid work.
Pamela Heaton, Ph.D. (Committee Chair)
Mahesh Fuldeore, BS. Pharmacy Ph.D. M. (Committee Member)
Steven Hass, Ph.D. (Committee Member)
Jill Boone, Pharm.D. (Committee Member)
Teresa Cavanaugh, Pharm.D. (Committee Member)
Leigh Wang, Ph.D. (Committee Member)
170 p.

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Citations

  • Tundia, N. (n.d.). Validation of the Health-Related Productivity Questionnaire and U.S. Population Norms [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378112340

    APA Style (7th edition)

  • Tundia, Namita. Validation of the Health-Related Productivity Questionnaire and U.S. Population Norms. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378112340.

    MLA Style (8th edition)

  • Tundia, Namita. "Validation of the Health-Related Productivity Questionnaire and U.S. Population Norms." Doctoral dissertation, University of Cincinnati. Accessed MARCH 28, 2024. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378112340

    Chicago Manual of Style (17th edition)