Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


8012.pdf (543.29 KB)

ETD Abstract Container

Abstract Header

Baroreflex Sensitivity after Adenotonsillectomy in Children with Obstructive Sleep Apnea during Wakefulness and Sleep

Crisalli, Joseph A, M.D.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384334068

Abstract Details

2013, MS, University of Cincinnati, Medicine: Epidemiology (Environmental Health).
Study Objectives: Children with obstructive sleep apnea have blunted baroreflex sensitivity and increased blood pressure variability. The aim of the study was to test the hypothesis that treatment of sleep apnea by adenotonsillectomy results in significant improvement of baroreflex sensitivity, lowering of blood pressure and blood pressure variability, and an increase in vagal heart rate modulation. Study Design: One hundred and ninety four children aged 9.6 ± 2.3 years were enrolled; 133 had obstructive sleep apnea and 61 were healthy controls. For children with sleep apnea, polysomnography with 3-lead electrocardiography and continuous blood pressure was performed before adenotonsillectomy, then 6 weeks and 6 months postoperatively. Controls underwent the same assessment at study entry and 6 months later. Spontaneous baroreflex sensitivity was measured in the time and frequency domains. Data analyses were performed for available and complete cases. Results: Children with sleep apnea experienced postoperatively an increase in baroreflex sensitivity and decrease in blood pressure variability during wakefulness and sleep. Decreases in blood pressure during sleep and in heart rate during wakefulness were also observed. The improvement in baroreflex sensitivity was predicted by the change in the apnea-hypopnea and arousal indices. A normal pattern of rising baroreflex sensitivity during the night was restored in children with severe apnea after surgery. However, baroreflex sensitivity did not completely normalize after treatment. Conclusion: Treatment of obstructive sleep apnea in children by adenotonsillectomy is associated with gradual improvement in known risk factors for cardiovascular disease. Complete normalization of baroreflex sensitivity was not achieved 6 months postoperatively.
Erin Nicole Haynes, Ph.D. (Committee Chair)
Rhonda VanDyke, Ph.D. (Committee Member)
36 p.
Surgery
sleep apnea; baroreflex; tonsillectomy; hypertension; blood pressure variability

Recommended Citations

Citations

  • Crisalli, M.D., J. A. (2013). Baroreflex Sensitivity after Adenotonsillectomy in Children with Obstructive Sleep Apnea during Wakefulness and Sleep [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384334068

    APA Style (7th edition)

  • Crisalli, M.D., Joseph. Baroreflex Sensitivity after Adenotonsillectomy in Children with Obstructive Sleep Apnea during Wakefulness and Sleep. 2013. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384334068.

    MLA Style (8th edition)

  • Crisalli, M.D., Joseph. "Baroreflex Sensitivity after Adenotonsillectomy in Children with Obstructive Sleep Apnea during Wakefulness and Sleep." Master's thesis, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384334068

    Chicago Manual of Style (17th edition)

ucin1384334068
532
© 2013, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.