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Hyperthermic ablation of MDA-MB-231 human mammary gland adenocarcinoma mediated by the photothermal effect of poly(acrylic acid) coated magnetite nanoparticles, efficacy and applicability for novel cancer treatment

Dunn, Andrew W
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384849962

Abstract Details

2013, MS, University of Cincinnati, Engineering and Applied Science: Biomedical Engineering.
Breast cancer accounts for 29% of the newly diagnosed patents and 15% of the total cancer related deaths in women in 2012. This makes breast cancer the leading antagonist in newly diagnosed cases and second in cancer related deaths in women.1 Present treatments include: lumpectomy, mastectomy, chemotherapy, radiotherapy, and cryoablation.2 Surgical resection of carcinogenic tissue can be an effective treatment method if the cancerous region possesses well defined boundaries between healthy and tumorous tissue. However surgical resection is a fully invasive procedure marked by the need to produce a clean, tumor free edge around the resected tissue. This places restrictions on the size and location of tumoral masses eligible for surgical resection. Furthermore ablative techniques, such as radiofrequency and cryoablation, lack specificity in tumor targeting and require image guidance, this can cause unwanted death of healthy tissue. Chemotherapy lacks specificity and greatly effects regional and distal regions by inducing necrotic and apoptotic domains throughout the body, generating many adverse side effects.
Balakrishna Haridas, Ph.D. (Committee Chair)
T. Douglas Mast, Ph.D. (Committee Member)
David Mast, Ph.D. (Committee Member)
Giovanni Pauletti, Ph.D. (Committee Member)
Donglu Shi, Ph.D. (Committee Member)
65 p.
Biomedical Research
Nanoparticles; Magnetite; Polyacrylic Acid; Cancer; Hyperthermia; Ablation

Recommended Citations

Citations

  • Dunn, A. W. (2013). Hyperthermic ablation of MDA-MB-231 human mammary gland adenocarcinoma mediated by the photothermal effect of poly(acrylic acid) coated magnetite nanoparticles, efficacy and applicability for novel cancer treatment [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384849962

    APA Style (7th edition)

  • Dunn, Andrew. Hyperthermic ablation of MDA-MB-231 human mammary gland adenocarcinoma mediated by the photothermal effect of poly(acrylic acid) coated magnetite nanoparticles, efficacy and applicability for novel cancer treatment. 2013. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384849962.

    MLA Style (8th edition)

  • Dunn, Andrew. "Hyperthermic ablation of MDA-MB-231 human mammary gland adenocarcinoma mediated by the photothermal effect of poly(acrylic acid) coated magnetite nanoparticles, efficacy and applicability for novel cancer treatment." Master's thesis, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384849962

    Chicago Manual of Style (17th edition)

ucin1384849962
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© 2013, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.