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The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics

Minter, Anne C
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

Abstract Details

2013, MS, University of Cincinnati, Allied Health Sciences: Nutrition.
Adiponectin modulates a range of human physiological processes related to metabolism and inflammation. Human milk is known to contain adiponectin in a wide range of concentrations. Variation in adiponectin concentration remains poorly understood; thus we sought to determine its maternal anthropometric and metabolic correlates. The morning after an overnight fast, lactating mothers (N=20) provided an aliquot of milk from a complete breast expression, and underwent an oral glucose tolerance test (OGTT) and anthropometric measurement. Fasting serum (total and HMW) adiponectin and human milk adiponectin were determined by ELISA. Insulin and glucose concentrations were determined by standard clinical assays. Correlates of human milk adiponectin were evaluated using Spearman rank-order correlation coefficient (r). Adiponectin concentrations (mean [min-max] ng/mL) were: human milk, 30.7 (6.9-92.49) and serum total, 6489 (1356-20257). Human milk adiponectin and serum total adiponectin were positively correlated (r=0.45, p=0.048). Human milk adiponectin was not correlated with other full-body measures of maternal metabolic status (fasting glucose, fasting insulin, insulin sensitivity, or insulin secretion). Likewise, full-body anthropometrics (weight and BMI) were not correlated with milk adiponectin concentration. Reflective of more localized fat depots, body circumference measures became more strongly correlated with human milk adiponectin concentration with increasing proximity to the breast. Spearman correlations of circumferences with human milk adiponectin concentration were hip (r=-0.32, p=0.164); iliac crest (r=-0.46, p=0.039); waist (r=-0.50, p=0.025); under breast (r=-0.56, p=0.011). Our novel finding that under-breast circumference was the strongest correlate of human milk adiponectin suggests that the localized fat depots of the breast may be an important source of adiponectin in human milk. Further studies of how the specific fat depots of the breast and upper body independently influence the breast macro-environment and the bioactives in human milk are warranted.
Seung-Yeon Lee, Ph.D. (Committee Chair)
Laurie Ann Nommsen-Rivers, Ph.D. (Committee Member)
Ardythe Luxion Morrow, Ph.D. (Committee Member)
Abigail Peairs, Ph.D. (Committee Member)
43 p.
Nutrition
Hormones in human milk; Human milk adiponectin concentration; Milk adiponectin and maternal anthropometrics; Milk adiponectin and Metabolic measures; Lactation; Breastfeeding

Recommended Citations

Citations

  • Minter, A. C. (2013). The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

    APA Style (7th edition)

  • Minter, Anne. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. 2013. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012.

    MLA Style (8th edition)

  • Minter, Anne. "The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics." Master's thesis, University of Cincinnati, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

    Chicago Manual of Style (17th edition)

ucin1384850012
371
© 2013, some rights reserved.Creative Commons License The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics by Anne C Minter is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.