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β-cyclodextrin Modified Metal Nanoparticles for the Detection of Cholesterol using SERS

Milarcik, April N.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396453636

Abstract Details

2014, MS, University of Cincinnati, Arts and Sciences: Chemistry.
β-cyclodextrin modified metal nanoparticles were investigated for the detection of cholesterol using Surface Enhanced Raman Spectroscopy (SERS).Gold and silver nanoparticles were reduced and capped with β-cyclodextrin or modified by polyelectrolyte assembly using PAH and β-cyclodextrin modified PAA polymers. The Raman spectrum of cholesterol should be enhanced due to formation of an inclusion complex with β-cyclodextrin and therefore location close to the metal surface. Suitable detection limit and repeatability for this application was not obtained through successive experiments to improve both the nanoparticles and the measurement parameters. Further improvements of β-cyclodextrin modified metal nanoparticles could provide a detection method for cholesterol using SERS with suitable repeatability and detection limit.
Peng Zhang, Ph.D. (Committee Chair)
Joseph Caruso, Ph.D. (Committee Member)
William Heineman, Ph.D. (Committee Member)
41 p.
Analytical Chemistry
SERS; cyclodextrin; nanoparticles; cholesterol

Recommended Citations

Citations

  • Milarcik, A. N. (2014). β-cyclodextrin Modified Metal Nanoparticles for the Detection of Cholesterol using SERS [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396453636

    APA Style (7th edition)

  • Milarcik, April. β-cyclodextrin Modified Metal Nanoparticles for the Detection of Cholesterol using SERS. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396453636.

    MLA Style (8th edition)

  • Milarcik, April. "β-cyclodextrin Modified Metal Nanoparticles for the Detection of Cholesterol using SERS." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396453636

    Chicago Manual of Style (17th edition)

ucin1396453636
917
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This open access ETD is published by University of Cincinnati and OhioLINK.