Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


10387.pdf (893.92 KB)

ETD Abstract Container

Abstract Header

Parents' Likelihood to Share Their Child’s CYP2D6 Pharmacogenetic Result

McLaughlin, Brooke M
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396522899

Abstract Details

2014, MS, University of Cincinnati, Medicine: Genetic Counseling.
Introduction: The most commonly prescribed opioid analgesic to relieve mild to moderate pain is codeine. Analgesic effects depend on conversion of codeine to morphine through the cytochrome P-450 2D6 enzyme, CYP2D6. Children who are ultra-rapid metabolizers of codeine are at increased risk for adverse drug reactions, including death, when prescribed codeine. Children who are poor metabolizers of codeine do not benefit from its analgesic property. Potential benefits of knowing and sharing the CYP2D6 pharmacogenetic result in a pediatric setting include increased monitoring for adverse drug reactions or change in prescribed medication depending on metabolizer status. To our knowledge, no studies have examined the impact of returning the children’s CYP2D6 pharmacogenetic research result to parents, including with whom parents’ intend to share their child’s pharmacogenetic test result. The aim of this study was to determine parents’ reported likelihood of sharing their child’s CYP2D6 pharmacogenetic research result with their child’s primary care physician, pharmacist, and child after receiving the research result, and whether there was a difference in the likelihood of sharing the result between parents whose children had a history of exposure to a prescribed opioid and parents whose children had no history of exposure to a prescribed opioid. Hypothesis: There will be a difference between parents’ likelihood to share the result in the exposed and unexposed groups. Methods: Target population was parents with children younger than 18 years and who were previously exposed (cases) or naive (controls) to opioids. Participants were recruited through mailed letters of invitation and follow-up phone calls with non-respondents. Parents provided verbal and written consent and confirmed their child’s opioid exposure history via phone. Cincinnati Children’s Hospital Medical Center’s Molecular Laboratory performed genetic testing on the child’s stored DNA. Participants received the CYP2D6 research result from an advanced practice nurse in genetics. Intent to share the research result was assessed via a telephone-administered questionnaire immediately after result disclosure. Results: Among 46 participants, 97.8% reported they were likely to share the result with the child’s doctor, 65.2% were likely to share the result with the child’s pharmacist, 76.0% were likely to share the result with the child within the next year, and 81.8% were likely to the share result with the child before the child turns 18 years old. All participants agreed the parent and provider could use the test result to improve care for the child. No statistically significant differences were detected between the likelihood to share the result between the exposed and unexposed groups. Conclusion: Regardless of prescribed opioid exposure, parents of children who had CYP2D6 genetic testing believe there is clinical utility in the test and are likely to share the result with the child’s doctor, pharmacist, and child. Providers, especially physicians, should consider increasing their knowledge and collaborating with pharmacists/ geneticists to better understand the importance of CYP2D6 pharmacogenetic testing and how those results may be used to reduce adverse drug reactions in children.
Melanie Myers, Ph.D. (Committee Chair)
Cynthia Prows, R.N. M.S.N. (Committee Member)
Xue Zhang, Ph.D. (Committee Member)
77 p.
Genetics
Pharmacogenetic; Sharing Result; CYP2D6; Parent; Child

Recommended Citations

Citations

  • McLaughlin, B. M. (2014). Parents' Likelihood to Share Their Child’s CYP2D6 Pharmacogenetic Result [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396522899

    APA Style (7th edition)

  • McLaughlin, Brooke. Parents' Likelihood to Share Their Child’s CYP2D6 Pharmacogenetic Result. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396522899.

    MLA Style (8th edition)

  • McLaughlin, Brooke. "Parents' Likelihood to Share Their Child’s CYP2D6 Pharmacogenetic Result." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396522899

    Chicago Manual of Style (17th edition)

ucin1396522899
290
© 2014, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.