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Examining the Pediatric Epilepsy Surgery Population: The Prognostic Value of Central Nervous System Comorbidities in Probands and their Families

Qualmann, Krista J
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396524075

Abstract Details

2014, MS, University of Cincinnati, Medicine: Genetic Counseling.
Objective: To determine prevalence of central nervous system (CNS) comorbidities in pediatric patients undergoing epilepsy surgery and their families, and correlate these findings with long-term seizure outcome. Methods: Parents of children, age 0-17, with epilepsy who received resective surgery at Cincinnati Children’s Hospital Medical Center (CCHMC) between January 1, 2007 – June 30, 2012 were invited to participate in the study. A three-generation pedigree of epilepsy and its CNS comorbidities was collected via an online or telephone questionnaire from 52 participants. Surgery outcome classification by the International League Against Epilepsy (ILAE) scale was abstracted from an existing CCHMC clinical database. Proportions of affected probands and relatives were calculated and compared to the general population rates of individual comorbidities and the probands’ seizure outcome classification at their most recent follow-up evaluation. Results: Probands had significantly higher rates of ADHD, anxiety, autism, bipolar disorder, cognitive disability, depression and motor disability than the general population. First degree relatives (FDRs) had significantly higher rates of ADHD, autism, depression, and motor disability, and total relatives had higher rates of depression, epilepsy/seizures, and motor disability. Diagnoses of cognitive disability and autism in probands and autism in FDRs were associated with poorer surgery outcomes. Conclusions: Epilepsy probands and their families have significantly higher rates of CNS comorbidities than the general population. Poorer long-term seizure outcomes following resective surgery were associated with diagnoses of autism or cognitive disability in probands and autism in FDRs. Together these data support evidence for a common pathophysiological mechanism between epilepsy and its comorbidities.
Melanie Myers, Ph.D. (Committee Chair)
Hansel Matthias Greiner, M.D. (Committee Member)
Paul Horn, Ph.D. (Committee Member)
Christine Spaeth, M.S. C.G.C. (Committee Member)
73 p.
Genetics
Epilepsy; Intractable; Resective Surgery; Comorbidity; Family History

Recommended Citations

Citations

  • Qualmann, K. J. (2014). Examining the Pediatric Epilepsy Surgery Population: The Prognostic Value of Central Nervous System Comorbidities in Probands and their Families [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396524075

    APA Style (7th edition)

  • Qualmann, Krista. Examining the Pediatric Epilepsy Surgery Population: The Prognostic Value of Central Nervous System Comorbidities in Probands and their Families. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396524075.

    MLA Style (8th edition)

  • Qualmann, Krista. "Examining the Pediatric Epilepsy Surgery Population: The Prognostic Value of Central Nervous System Comorbidities in Probands and their Families." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396524075

    Chicago Manual of Style (17th edition)

ucin1396524075
276
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This open access ETD is published by University of Cincinnati and OhioLINK.