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Tissue Bioeffects during Ultrasound-Mediated Drug Delivery

Sutton, Jonathan T
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234692

Abstract Details

2014, PhD, University of Cincinnati, Engineering and Applied Science: Biomedical Engineering.
Ultrasound has been developed as both a valuable diagnostic tool and a potent promoter of beneficial tissue bioeffects for the treatment of cardiovascular disease. Vascular effects can be mediated by mechanical oscillations of circulating microbubbles, or ultrasound contrast agents, which may also encapsulate and shield a therapeutic agent in the bloodstream. Oscillating microbubbles can create stresses directly on nearby tissue or induce fluid effects that effect drug penetration into vascular tissue, lyse thrombi, or direct drugs to optimal locations for delivery. These investigations have spurred continued research into alternative therapeutic applications, such as bioactive gas delivery. This dissertation addresses a fundamental hypothesis in biomedical ultrasound: ultrasound-mediated drug delivery is capable of increasing the penetration of drugs across different physiologic barriers within the cardiovascular system, such as the vascular endothelium, blood clots, and smooth muscle cells.
Christy Holland, Ph.D. (Committee Chair)
Shiva Kumar Shanmukhappa, Ph.D. (Committee Member)
T. Douglas Mast, Ph.D. (Committee Member)
Gail Jean Pyne-Geithman, Ph.D. (Committee Member)
Marepalli Rao, Ph.D. (Committee Member)
154 p.
Biomedical Research
ultrasound; cavitation; drug delivery; bioactive gas; sonothromboylsis; ex vivo tissue

Recommended Citations

Citations

  • Sutton, J. T. (2014). Tissue Bioeffects during Ultrasound-Mediated Drug Delivery [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234692

    APA Style (7th edition)

  • Sutton, Jonathan. Tissue Bioeffects during Ultrasound-Mediated Drug Delivery. 2014. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234692.

    MLA Style (8th edition)

  • Sutton, Jonathan. "Tissue Bioeffects during Ultrasound-Mediated Drug Delivery." Doctoral dissertation, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397234692

    Chicago Manual of Style (17th edition)

ucin1397234692
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This open access ETD is published by University of Cincinnati and OhioLINK.