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Dependence of Duration and Frequency on Location Specific Vascular Damage in the Rat Tail Model

Kim, Brian Y
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397734478

Abstract Details

2014, MS, University of Cincinnati, Engineering and Applied Science: Mechanical Engineering.
Hand-Arm Vibration Syndrome (HAVS) is an injury that consists of vascular and musculoskeletal disorders caused by hand-transmitted vibration exposure to industrial workers. Current International Standard Organization (ISO) guidelines may be limited in predicting damage from exposures of known vibration frequency and duration. A rat tail model is used to investigate the effects of different frequencies and durations on vascular damage. For the experiment, 24 male Sprague-Dawley rats (250 ±15 gm) were used. Rat tails were vibrated at 125 Hz and 250 Hz (49 m/s2 r.m.s.) for 1D, 5D and 20D (D: day); for 4 hr/day. Structural damage of vessels was quantified by vacuole count using toluidine blue staining. The results were analyzed using one-way mixed model ANOVA at p< 0.05 level of significance to observe the effects of frequency and duration on vacuole formation. For the frequency effect, the structural damage increased at 125-Hz (24.94 ± 1.07) and peaked at 250-Hz (26.6 ± 1.07), evidenced by significant vacuole formation compared to the control group (10.91 ± 1.31). For the duration effect, the structural damage increased from 1D (22.75 ± 1.11) to 5D (25.0 ± 1.11) to 20D (29.58 ± 1.11), exhibiting significant vacuole formation when compared to their respective control groups (9.5 ± 1.91; 13.5 ± 1.91; 9.75 ± 1.91). Our results demonstrate that vascular damage in the form of gross-structural damage is significant at 125 Hz and 250 Hz, as well as 1D, 5D, and 20D. A limited-scope experiment to investigate a possible spatial resonance was inconclusive in analysis using gross-average values
Rupak Banerjee, Ph.D P.E. (Committee Chair)
J. Kim, Ph.D. (Committee Member)
David Thompson, Ph.D. (Committee Member)
45 p.
Mechanical Engineering
musculoskeletal disorders

Recommended Citations

Citations

  • Kim, B. Y. (2014). Dependence of Duration and Frequency on Location Specific Vascular Damage in the Rat Tail Model [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397734478

    APA Style (7th edition)

  • Kim, Brian. Dependence of Duration and Frequency on Location Specific Vascular Damage in the Rat Tail Model . 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397734478.

    MLA Style (8th edition)

  • Kim, Brian. "Dependence of Duration and Frequency on Location Specific Vascular Damage in the Rat Tail Model ." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397734478

    Chicago Manual of Style (17th edition)

ucin1397734478
310
© 2014, some rights reserved.Creative Commons License Dependence of Duration and Frequency on Location Specific Vascular Damage in the Rat Tail Model by Brian Y Kim is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.