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Evaluating the relationship between brain chemistry and postural balance in the Cincinnati Lead Study

Kuhnell, Pierce
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1409065672

Abstract Details

2014, MS, University of Cincinnati, Medicine: Biostatistics (Environmental Health).
This study investigated the relationship between brain metabolism and postural balance in the Cincinnati Lead Study (CLS) cohort. Postural balance testing was conducted at ages 7 to 12 years old, and proton magnetic resonance spectroscopy was acquired at ages 19 to 22 years old to evaluate metabolite concentrations of N-acetyl aspartate (NAA), creatine and phosphocreatine (Cr), cholines (Cho), myo-inositol (mI), and a composite of glutamate and glutamine (GLX). The results of this study show an association between poorer postural balance and decreased levels of NAA in the cerebellar vermis, increased levels of NAA in the basal ganglia, frontal white matter, and frontal gray matter, increased levels of Cr in the basal ganglia and frontal white matter, decreased levels of Cr in the temporal lobe, decreased levels of Cho in frontal white matter, parietal white matter, and cerebellar vermis, and increased levels of GLX in frontal gray matter, parietal white matter, and the cerebellar vermis. These findings indicate both a dysfunctional and a compensatory relationship between brain metabolism and postural balance depending on brain structure and location.
Paul Succop, Ph.D. (Committee Chair)
Amit Bhattacharya, Ph.D. (Committee Member)
Kim Cecil, Ph.D. (Committee Member)
Erin Nicole Haynes, Dr.P.H. (Committee Member)
27 p.
Biostatistics
Postural Balance; Magnetic Resonance Spectroscopy; Cincinnati Lead Study

Recommended Citations

Citations

  • Kuhnell, P. (2014). Evaluating the relationship between brain chemistry and postural balance in the Cincinnati Lead Study [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1409065672

    APA Style (7th edition)

  • Kuhnell, Pierce. Evaluating the relationship between brain chemistry and postural balance in the Cincinnati Lead Study. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1409065672.

    MLA Style (8th edition)

  • Kuhnell, Pierce. "Evaluating the relationship between brain chemistry and postural balance in the Cincinnati Lead Study." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1409065672

    Chicago Manual of Style (17th edition)

ucin1409065672
260
© 2014, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.