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Diagnosis of Coronary Artery Disease Using Pressure Drop Coefficient

Kolli, Kranthi Kumar

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2014, PhD, University of Cincinnati, Engineering and Applied Science: Mechanical Engineering.
The coronary circulation is influenced by two well-recognized pathophysiological serial resistances: epicardial stenosis and microvascular dysfunction. The independent evaluation of true ischemic severity of epicardial coronary stenosis and diseased myocardium is a challenge to current clinical diagnostic protocols. With the recent development of miniaturized sensor technology, it is possible to calculate current established hemodynamic parameters e.g. Fractional Flow Reserve (FFR; pressure derived) and Coronary Flow Reserve (CFR; flow derived) with minimal-invasive clinical procedures, which showed a high agreement with non-invasive stress testing. However, an important limitation in using either of the above single modality technique is the limited differentiation they offer between hemodynamic influences exerted by epicardial stenosis and the microcirculation.
Rupak Banerjee, Ph.D P.E. (Committee Chair)
Mohamed Effat, M.D. (Committee Member)
Frank Gerner, Ph.D. (Committee Member)
Tarek Helmy, Ph.D. (Committee Member)
Michael Kazmierczak, Ph.D. (Committee Member)
150 p.

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Citations

  • Kolli, K. K. (2014). Diagnosis of Coronary Artery Disease Using Pressure Drop Coefficient [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415615529

    APA Style (7th edition)

  • Kolli, Kranthi. Diagnosis of Coronary Artery Disease Using Pressure Drop Coefficient. 2014. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415615529.

    MLA Style (8th edition)

  • Kolli, Kranthi. "Diagnosis of Coronary Artery Disease Using Pressure Drop Coefficient." Doctoral dissertation, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415615529

    Chicago Manual of Style (17th edition)