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Selective Intra-Ophthalmic Artery Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience

Michaels, Samantha T, M.D.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415626121

Abstract Details

2014, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Selective intra-ophthalmic artery chemotherapy infusion (SIOAC) has been increasingly used in the management of retinoblastoma with the goal of minimization of therapy related toxicity and ocular salvage. Nineteen eyes in 17 patients with intraocular retinoblastoma received 87 SIOAC treatments between 2008 and 2013. While local reactions were common, mild and self-limited, rarer procedure-related adverse effects included bronchospasm, carboplatin anaphylaxis, transient lower extremity arterial thrombosis and reversible cerebral vasoconstriction. Neutropenia was more common with triple therapy cycles (melphalan, carboplatin and topotecan) when compared with single agent melphalan. Ocular salvage was achieved 11 of 19 eyes. Triple therapy was associated with improved rates of ocular salvage (p-value 0.0056). SIOAC can be effective therapy for intraocular retinoblastoma. Triple therapy seems more effective but also more myelosuppressive than single agent therapy. Larger scale clinical trials are necessary to better define the role of SIOAC.
Erin Nicole Haynes, Dr.P.H. (Committee Chair)
Adam C. Lane, Ph.D. (Committee Member)
James I. Geller, M.D. (Committee Member)
18 p.
Oncology
Intra-arterial chemotherapy; Retinoblastoma

Recommended Citations

Citations

  • Michaels, M.D., S. T. (2014). Selective Intra-Ophthalmic Artery Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415626121

    APA Style (7th edition)

  • Michaels, M.D., Samantha. Selective Intra-Ophthalmic Artery Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415626121.

    MLA Style (8th edition)

  • Michaels, M.D., Samantha. "Selective Intra-Ophthalmic Artery Chemotherapy for Advanced Intraocular Retinoblastoma: CCHMC Early Experience." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1415626121

    Chicago Manual of Style (17th edition)

ucin1415626121
315
© 2014, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.