Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


12822.pdf (364.29 KB)

ETD Abstract Container

Abstract Header

Vitamin D and Markers of Glucose Metabolism

Bitler, Chad
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416231511

Abstract Details

2014, MS, University of Cincinnati, Allied Health Sciences: Nutrition.
Objective: To examine whether serum vitamin D levels are related to markers of glucose metabolism as measured by A1C, fasting glucose, and fasting insulin, Design: Cross-sectional design using data from the National Health and Nutrition Examination Survey (NHANES), 2005 – 2006. Subjects: Non-diabetic adults, ages 20 years and older, with measures of serum vitamin D, fasting glucose, fasting insulin, and A1C were included in the study. Race/ethnicity, as reported by the subject, was categorized as Mexican American (N = 254), other Hispanic (N = 46), non-Hispanic White (N = 579), African American (N = 278), & multi-racial (N = 57) Methods: Data collected from 1214 adult participants in the National Health and Nutrition Examination Survey (NHANES) 2005 – 2006 was accessed via the public domain and analyzed using SAS Enterprise software, version 6.1. Pearson correlation, odds ratio, and chi-squared tests were performed to determine the strength and significance of the relationship between levels of serum vitamin D and A1C, fasting glucose, and fasting insulin status. Results: Serum vitamin D was inversely correlated with A1C (r = -0.12; p = < 0.0001), fasting glucose (r = -0.08; p = 0.005), and fasting insulin (r = -0.18; p = < 0.0001), across the study population. For the total study population, the likelihood of having an abnormal marker of glucose metabolism with adequate serum vitamin D (= 30 ng/mL) was reduced for fasting insulin, (OR = 0.40; 95% CI = 0.29 – 0.54) and A1C (OR = 0.67; 95% CI = 0.44 – 0.99) but not significant for glucose (OR = 0.78; 95% CI = 0.57 – 1.06). When racial and ethnic groups were subdivided, the only marker that remained significant was fasting insulin in the Caucasian (OR = 0.50; 95% CI = 0.34 – 0.73) and Mexican-American (OR = 0.16; 95% CI = 0.07 – 0.39) groups. Conclusion: The results of this study show an inverse association between serum vitamin D and A1C, fasting glucose, and fasting insulin. Adequate levels of serum vitamin D (= 30 ng/mL) was also found to be associated with reduced risk of impaired fasting insulin and A1C in the total population. In subgroups, the odds of having an abnormal insulin level was only significant in Mexican-American and non-Hispanic white participants. This data extends previous research and provides new evidence that serum vitamin D may play a role in glucose metabolism, which may have implications for the pathogenesis of type 2 diabetes.
Debra Ann Krummel, Ph.D. (Committee Chair)
Seung-Yeon Lee, Ph.D. (Committee Member)
53 p.
Nutrition
Vitamin D; Glucose Metabolism; A1C; Fasting glucose; Insulin

Recommended Citations

Citations

  • Bitler, C. (2014). Vitamin D and Markers of Glucose Metabolism [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416231511

    APA Style (7th edition)

  • Bitler, Chad. Vitamin D and Markers of Glucose Metabolism. 2014. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416231511.

    MLA Style (8th edition)

  • Bitler, Chad. "Vitamin D and Markers of Glucose Metabolism." Master's thesis, University of Cincinnati, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416231511

    Chicago Manual of Style (17th edition)

ucin1416231511
506
© 2014, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.