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Pilot Study of Attention Deficit Hyperactivity Disorder-related Behaviors in a Pediatric Ehlers-Danlos Syndrome-Hypermobility type Population

Reinert, Caitlin R.
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427796903

Abstract Details

2015, MS, University of Cincinnati, Medicine: Genetic Counseling.
Introduction: Clinical observation in the Cincinnati Children’s Hospital Medical Center (CCHMC) Connective Tissue Clinic as well as recent published research suggests a link between joint hypermobility and ADHD. However, existing studies are few in number and of limited clinical usefulness. The primary goal of this pilot study was to examine the proposed relationship between Ehlers-Danlos syndrome-Hypermobility type (EDS-HT) and attention-related behaviors in order to assess whether further, larger studies might be warranted. Methods: The parents of 12 children with EDS-HT seen in the CCHMC Connective Tissue Clinic (cases) and 7 non-hypermobile controls seen in a local pediatric office completed the Child Behavior Checklist (CBCL) to rate the participants on a variety of behaviors. Comparisons of t-scores for each CBCL scale were performed using Wilcoxon rank sum tests. T-scores were also dichotomized and proportions of borderline/clinical range scores (t score = 65) were compared between cases and controls using Fisher’s exact tests. Results: Compared with controls, cases showed significantly higher t-scores on the Sluggish Cognitive Tempo (SCT) scale (p=0.006), and scores on the SCT scale correlated highly with scores on the Attention Problems syndrome scale (R=0.8298) and ADHD Problems DSM-oriented scale (R=0.6981). When scores were dichotomized, the two attention-related CBCL scales were among the scales that showed the largest difference in proportion of cases with t-scores = 65 (ADHD Problems DSM-oriented scale, p=0.147; Attention Problems syndrome scale, p=0.333). Conclusion: The significant findings in the SCT scale and observed trends in other attention-related scales indicate that larger future studies are needed to further elucidate the relationship between EDS-HT and attention problems. An association between EDS-HT and ADHD may influence clinical management of patients with both disorders.
Derek Neilson, M.D. (Committee Chair)
Jodie Johnson, M.S. C.G.C. (Committee Member)
Xue Zhang, Ph.D. (Committee Member)
Jeffery Epstein, Ph.D. (Committee Member)
Genetics
Ehlers-Danlos syndrome Hypermobility; attention related behaviors;

Recommended Citations

Citations

  • Reinert, C. R. (2015). Pilot Study of Attention Deficit Hyperactivity Disorder-related Behaviors in a Pediatric Ehlers-Danlos Syndrome-Hypermobility type Population [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427796903

    APA Style (7th edition)

  • Reinert, Caitlin. Pilot Study of Attention Deficit Hyperactivity Disorder-related Behaviors in a Pediatric Ehlers-Danlos Syndrome-Hypermobility type Population. 2015. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427796903.

    MLA Style (8th edition)

  • Reinert, Caitlin. "Pilot Study of Attention Deficit Hyperactivity Disorder-related Behaviors in a Pediatric Ehlers-Danlos Syndrome-Hypermobility type Population." Master's thesis, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427796903

    Chicago Manual of Style (17th edition)

ucin1427796903
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This open access ETD is published by University of Cincinnati and OhioLINK.