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Targeting the DEK oncogene in head and neck squamous cell carcinoma: functional and transcriptional consequences

Adams, Allie K
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882536

Abstract Details

2015, PhD, University of Cincinnati, Medicine: Cancer and Cell Biology.
Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignancies worldwide with over 50,000 new cases in the United States each year. For many years tobacco and alcohol use were the main etiological factors; however, it is now widely accepted that human papillomavirus (HPV) infection accounts for at least one-quarter of all HNSCCs. HPV+ and HPV- HNSCCs are studied as separate diseases as their prognosis, treatment, and molecular signatures are distinct. Five-year survival rates of HNSCC hover around 40-50%, and novel therapeutic targets and biomarkers are necessary to improve patient outcomes.
Susanne Wells, Ph.D. (Committee Chair)
Keith Andrew Casper, M.D. (Committee Member)
Ronald Waclaw, Ph.D. (Committee Member)
Peter Stambrook, Ph.D. (Committee Member)
Susan Waltz, Ph.D. (Committee Member)
Kathryn Wikenheiser-Brokamp, M.D. Ph.D. (Committee Member)
140 p.
Cellular Biology
DEK; IRAK1; HNSCC; p63; HPV

Recommended Citations

Citations

  • Adams, A. K. (2015). Targeting the DEK oncogene in head and neck squamous cell carcinoma: functional and transcriptional consequences [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882536

    APA Style (7th edition)

  • Adams, Allie. Targeting the DEK oncogene in head and neck squamous cell carcinoma: functional and transcriptional consequences. 2015. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882536.

    MLA Style (8th edition)

  • Adams, Allie. "Targeting the DEK oncogene in head and neck squamous cell carcinoma: functional and transcriptional consequences." Doctoral dissertation, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882536

    Chicago Manual of Style (17th edition)

ucin1427882536
614
© 2015, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.