Skip to Main Content
 

Global Search Box

 
 
 
 

Files

ETD Abstract Container

Abstract Header

Role of the Prefrontal Glucocorticoid Receptor in Synaptic, Neuroendocrine, and Behavioral Stress Adaptation

McKlveen, Jessica M.

Abstract Details

2015, PhD, University of Cincinnati, Medicine: Neuroscience/Medical Science Scholars Interdisciplinary.
Real or perceived threats to homeostasis activate the hypothalamic-pituitary-adrenocortical (HPA) axis, culminating in the secretion of glucocorticoids. Glucocorticoids promote energy redistribution and are critical for survival. While glucocorticoids initiate adaptive processes that generate energy for coping, prolonged glucocorticoid secretion may become deleterious. The medial prefrontal cortex (mPFC) expresses glucocorticoid receptors (GR) and is thought to be a key site for glucocorticoid-mediated regulation responses to stress. Notably, Major Depressive Disorder (MDD) is commonly associated with alterations in Brodmann area 25 metabolism and hypercortisolemia, suggesting a link between aberrant glucocorticoid signaling and prefrontal function. Thus, understanding how glucocorticoid-mediated adaptation can ultimately lead to pathology is of paramount importance for the treatment of stress-related disorders, such as MDD.
James Eliassen, Ph.D. (Committee Chair)
Eric Krause, Ph.D. (Committee Member)
Stephen Benoit, Ph.D. (Committee Member)
James Herman, Ph.D. (Committee Member)
Renu Sah, Ph.D. (Committee Member)
Kim Seroogy, Ph.D. (Committee Member)
172 p.

Recommended Citations

Citations

  • McKlveen, J. M. (2015). Role of the Prefrontal Glucocorticoid Receptor in Synaptic, Neuroendocrine, and Behavioral Stress Adaptation [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882983

    APA Style (7th edition)

  • McKlveen, Jessica. Role of the Prefrontal Glucocorticoid Receptor in Synaptic, Neuroendocrine, and Behavioral Stress Adaptation. 2015. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882983.

    MLA Style (8th edition)

  • McKlveen, Jessica. "Role of the Prefrontal Glucocorticoid Receptor in Synaptic, Neuroendocrine, and Behavioral Stress Adaptation." Doctoral dissertation, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427882983

    Chicago Manual of Style (17th edition)