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Single Position Focusing of Cells in a Microchannel System

Zandi, Matthew A
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1428066046

Abstract Details

2015, MS, University of Cincinnati, Engineering and Applied Science: Chemical Engineering.
The ability to focus and separate cells is invaluable in the area of cellular research. Inertial microfluidics uses the intrinsic physical properties of cells for manipulation and separation. Previous microfluidic devices use external controls in order to achieve focusing of cells into a single position. In this thesis we have examined a microfluidic device that exhibits inertial lift force as the only control to manipulate cells into a single position. We demonstrated that this device could handle variation of cell size and still achieve high efficiency and throughput. The device was verified for efficiency, throughput, recovery, and cell viability. The efficiency was reported at 99%, the throughput was reported at 850 cells per second, the recovery was reported at 99% and the cell viability were shown by incubation post device run. The simplified device offers many advantages over current methods, due to the simplified geometry, the ability for modification, and the flexibility in sample size variation.
Chia Chi Ho, Ph.D. (Committee Chair)
Carlos Co, Ph.D. (Committee Member)
Vadim Guliants, Ph.D. (Committee Member)
22 p.
Chemical Engineering
Focusing; Cell; Microchannel; Inertial Force

Recommended Citations

Citations

  • Zandi, M. A. (2015). Single Position Focusing of Cells in a Microchannel System [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1428066046

    APA Style (7th edition)

  • Zandi, Matthew. Single Position Focusing of Cells in a Microchannel System. 2015. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1428066046.

    MLA Style (8th edition)

  • Zandi, Matthew. "Single Position Focusing of Cells in a Microchannel System." Master's thesis, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1428066046

    Chicago Manual of Style (17th edition)

ucin1428066046
547
© 2015, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.