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Copper-based Point-of-care Sensor for Heavy Metal Determination in Public Health

Pei, Xing
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439309640

Abstract Details

2015, PhD, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
This work describes development of the first copper (Cu)-based sensor for determination of heavy metals, such as zinc (Zn), lead (Pb) and cadmium (Cd). Heavy metals require careful monitoring, yet current methods are too complex for a point-of-care (POC) system. Electrochemistry offers a simple approach to metal determination, but traditional electrodes are difficult or expensive to microfabricate, preventing wide-spread use. The sensor described in this work features a new low-cost electrode material which offers simple fabrication, while maintaining competitive electrochemical performance. The sensors of this work were fabricated by photolithography and electroplating to form the three electrodes used for anodic stripping voltammetry (ASV): a Cu working electrode, a Cu auxiliary electrode, and a Cu/CuCl2 reference electrode. They were demonstrated to be sufficiently stable for at least one electrochemical measurement through the careful examination of each electrode. For the metals of interest, the Cu-based sensors exhibited limit of detection (LOD) of 140 nM (9.0 ppb) for Zn, 21 nM (4.4 ppb) for Pb and 118 nM (13 ppb) for Cd. The sensor was also used to demonstrate measurements in biological (blood, serum) and environmental (surface water) sample matrices. These results demonstrate the advantageous qualities of this POC electrochemical sensor for public health applications, which include a small sample volume (µL-scale), reduced cost, short response time and high accuracy at low concentrations of analyte.
Ian Papautsky, Ph.D. (Committee Chair)
Adam F. Bange, Ph.D. (Committee Member)
Chong Ahn, Ph.D. (Committee Member)
Fred Beyette, Ph.D. (Committee Member)
William Heineman, Ph.D. (Committee Member)
148 p.
Analytical Chemistry
Copper-based sensor; heavy metal; zinc; lead; cadmium; anodic stripping voltammetry

Recommended Citations

Citations

  • Pei, X. (2015). Copper-based Point-of-care Sensor for Heavy Metal Determination in Public Health [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439309640

    APA Style (7th edition)

  • Pei, Xing. Copper-based Point-of-care Sensor for Heavy Metal Determination in Public Health. 2015. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439309640.

    MLA Style (8th edition)

  • Pei, Xing. "Copper-based Point-of-care Sensor for Heavy Metal Determination in Public Health." Doctoral dissertation, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439309640

    Chicago Manual of Style (17th edition)

ucin1439309640
793
© 2015, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.