Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


19454.pdf (3.09 MB)

ETD Abstract Container

Abstract Header

Intra-animal and Inter-animal Variations in the Biomechanical Properties of Tracheal Cartilage Rings

Karkhanis, Teja
http://orcid.org/0000-0002-2958-6047
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037942

Abstract Details

2015, MS, University of Cincinnati, Engineering and Applied Science: Biomedical Engineering.
Cartilage rings in the trachea are primarily responsible for structural stability of the trachea and to prevent its collapse over the range of intrathoracic pressures encountered in-vivo. The underlying biomechanical properties of the cartilage rings critical to this function are unknown. This study was designed to determine the zero stress state, structural properties – initial and tangent stiffness, and load relaxation (% of initial load) of the tracheal rings and material properties of the tracheal cartilage. These properties would eventually be used to create the biomechanical design requirements for a tracheal exostent which would then be used in pediatric patients suffering from long segment congenital tracheal stenosis. Primary goal of this study was to determine the inter-animal variations of these properties for 3-6 month old lamb and to determine if these properties vary within animals with the anatomical location of the ring on the trachea. Cartilage rings were isolated from the cranial, mid and caudal sections of tracheas from eight lambs (3-6 month old). The rings were cut posteriorly to allow them to reach zero stress state and corresponding opening angles were measured. The rings at zero stress state were further tested either in radial tension or radial compression at a constant rate of deformation. The rings tested in radial tension were held at a constant radial displacement at the end of the test and load relaxation was recorded over 15 minutes. The data from these tests was used to calculate the initial and tangent stiffness and load relaxation of the rings. Modulus was calculated from analytical models for the ring test configurations based on curved beam theory. The results obtained showed large inter-animal variations in the tracheal ring major and minor diameters, width and thickness of rings (geometry at no-load), opening angle (zero stress state geometry), initial and tangent stiffness, load relaxation and modulus. Moreover, the minor diameter, thickness, width and initial stiffness showed a significant decrease from cranial to caudal section of trachea. Similarly, the major diameter, opening angle and load relaxation showed a significant increase from cranial to caudal section of trachea. The tangent stiffness and modulus did not show a trend with respect to the anatomical location. The results of this study provide the biomechanical design requirements for the tracheal exostent specific to circumferential loading of the exostent. It also provides a baseline for any further tracheal studies using this animal model.
Balakrishna Haridas, PH.D. (Committee Chair)
Farhan Zafar, M.D. (Committee Member)
Vasille Nistor, Ph.D. (Committee Member)
Marepalli Rao, Ph.D. (Committee Member)
86 p.
Engineering
Trachea; cartilage rings; Biomechanical properties; Congenital Tracheal Stenosis

Recommended Citations

Citations

  • Karkhanis, T. (2015). Intra-animal and Inter-animal Variations in the Biomechanical Properties of Tracheal Cartilage Rings [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037942

    APA Style (7th edition)

  • Karkhanis, Teja. Intra-animal and Inter-animal Variations in the Biomechanical Properties of Tracheal Cartilage Rings. 2015. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037942.

    MLA Style (8th edition)

  • Karkhanis, Teja. "Intra-animal and Inter-animal Variations in the Biomechanical Properties of Tracheal Cartilage Rings." Master's thesis, University of Cincinnati, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1448037942

    Chicago Manual of Style (17th edition)

ucin1448037942
799
© 2015, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.