Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


19662.pdf (1.81 MB)

ETD Abstract Container

Abstract Header

The Ron Receptor Tyrosine Kinase as a Mediator of Inflammation and Tumorigenesis

Paluch, Andrew M
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1455208865

Abstract Details

2016, MS, University of Cincinnati, Medicine: Cancer and Cell Biology.
Prostate cancer (PCa) is one of the leading causes of death among men in the United States, particularly given that many patients will present with or develop castration-resistant prostate cancer. Identifying novel biomarkers is therefore essential to develop new therapeutics for the treatment of this disease. While current therapeutics have targeted the androgen receptor, a major driver in the development and progression of PCa, this has been met with limited success. Understanding the role of other potent drivers of PCa is paramount to successful patient outcomes. One potential driver may be the Ron receptor tyrosine kinase. Chronic inflammation has been suggested to be a precursor for the development of PCa and interestingly, Ron has been shown previously to be a regulator of macrophage inflammatory responses. In addition, new studies have suggested its role in oncogenesis. While there are Ron inhibitors in clinical trials for the treatment of several malignancies, there have been no trials looking at Ron inhibition in PCa. Therefore, understanding how Ron functions to mediate inflammatory responses and drive oncogenic events are crucial to potentially utilizing Ron inhibitors for the treatment of prostate cancer.
Tatiana Kalin, M.D.Ph.D. (Committee Chair)
Rafeeq Habeebahmed, Ph.D. (Committee Member)
Atsuo Sasaki, Ph.D. (Committee Member)
39 p.
Cellular Biology
prostate cancer; ron receptor; receptor tyrosine kinase; inflammation; castration-resistant prostate cancer; androgen receptor

Recommended Citations

Citations

  • Paluch, A. M. (2016). The Ron Receptor Tyrosine Kinase as a Mediator of Inflammation and Tumorigenesis [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1455208865

    APA Style (7th edition)

  • Paluch, Andrew. The Ron Receptor Tyrosine Kinase as a Mediator of Inflammation and Tumorigenesis. 2016. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1455208865.

    MLA Style (8th edition)

  • Paluch, Andrew. "The Ron Receptor Tyrosine Kinase as a Mediator of Inflammation and Tumorigenesis." Master's thesis, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1455208865

    Chicago Manual of Style (17th edition)

ucin1455208865
322
© 2016, some rights reserved.Creative Commons License The Ron Receptor Tyrosine Kinase as a Mediator of Inflammation and Tumorigenesis by Andrew M Paluch is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.