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Synthesis, Characterization and Application of SERS-active Metal Nanoparticles

Zhou, Yan
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458644099

Abstract Details

2016, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
This dissertation covers three areas which I have worked on while pursuing my degree. The first chapter includes an introduction of the work presented. The second and third chapters are devoted to design and synthesis a new class of nanoparticles and the related Surface-enhanced Raman Spectroscopy (SERS) and Surface-enhanced Fluorescence (SEF) investigation. Chapter two reported a new strategy to prepare a class of SERS-active nanoparticles with reporters embedded between Au-core/Ag-shell. These core-shell nanoparticles can find use as SERS-tags for Raman-based assay with strong SERS signals and good stability. In chapter three, by adjusting the spacing and the dye position between the core and the shell, we have successfully observed the simultaneous SEF and SERS from our Au-core/Ag-shell nanoparticles. The combination of SEF and SERS onto single nanoparticles is highly desirable to improve the accuracy and sensitivity in detection applications, which has drawn increasing attention in recent years to study the two effects on the same nanostructures. The chapter four covers the applications of previously developed SERS-active nanomaterials. Using the metal core-shell nanoparticles as the SERS substrates, we have successfully performed quantitative SERS measurements of three different types of analytes by embedding an internal reference between the Au core and Ag shell. This strategy provides great flexibility in the choice of the internal references and analytes, and also allows quantitative SERS measurements of the analytes in the solution.
Peng Zhang, Ph.D. (Committee Chair)
Bruce Ault, Ph.D. (Committee Member)
Hairong Guan, Ph.D. (Committee Member)
108 p.
Analytical Chemistry
Nanoparticles; Raman spectroscopy; SERS; Fluorescence spectroscopy; core shell nanoparticles

Recommended Citations

Citations

  • Zhou, Y. (2016). Synthesis, Characterization and Application of SERS-active Metal Nanoparticles [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458644099

    APA Style (7th edition)

  • Zhou, Yan. Synthesis, Characterization and Application of SERS-active Metal Nanoparticles. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458644099.

    MLA Style (8th edition)

  • Zhou, Yan. "Synthesis, Characterization and Application of SERS-active Metal Nanoparticles." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1458644099

    Chicago Manual of Style (17th edition)

ucin1458644099
516
© 2016, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.