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Enhancement of Silver Nanoparticles in Fluorescence, Raman and Singlet Oxygen Generation

Zhang, Jinnan

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2016, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
In this dissertation, we explored the syntheses and characterizations of silver nanoparticles and its application in fluorescence, Raman and singlet oxygen generation. In the first project, we report the observation of significantly enhanced fluorescence from molecules placed inside a silver nanocavity, as compared to those without the silver coating. Meso-tetra(4-carboxyphenyl) porphine (TCPP) is used as the fluorophore molecule. The fluorophores werefirst embedded in the porous TiO2 colloid nanoparticles. Then additional TiO2 was used as a spacer layer, onto which a controlled amount of silver is deposited. The final nanostructure consisted of a TiO2–TCPP core, a pure TiO2 layer and a silver nanoshell. In essence, the fluorophores (TCPP molecules) were placed inside a metallic nanocavity. The result shows the observation of >50-fold fluorescence enhancement for fluorophores trapped inside a silver nanocavity. In the second project, we report a quantitative SERS measurement scheme based on the magnetic microspheres and AgNPs to detect target DNA. This detection displays both high sensitivity (down to 10 nM) and high specificity (differentiating single-base mismatched targets). The use of magnetic microspheres facilitates rapid, efficient and reproducible sample preparation. The results demonstrate great potential of using SERS for quantitative DNA detection. In the third project, we report the synthesis of the general platform for singlet oxygen production which significantly increased the singlet oxygen production of the photosensitizers, in some cases by up to 26 times. It is observed that the presence of silver core in Ag@SiO2@mSiO 2@HP core-shell structure would significantly increase the singlet oxygen generation, and the thickness of either solid SiO 2 shell or mesoporous SiO2 could affect the singlet oxygen generation as well.
Peng Zhang, Ph.D. (Committee Chair)
Hairong Guan, Ph.D. (Committee Member)
James Mack, Ph.D. (Committee Member)
90 p.

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Citations

  • Zhang, J. (2016). Enhancement of Silver Nanoparticles in Fluorescence, Raman and Singlet Oxygen Generation [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444904

    APA Style (7th edition)

  • Zhang, Jinnan. Enhancement of Silver Nanoparticles in Fluorescence, Raman and Singlet Oxygen Generation. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444904.

    MLA Style (8th edition)

  • Zhang, Jinnan. "Enhancement of Silver Nanoparticles in Fluorescence, Raman and Singlet Oxygen Generation." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460444904

    Chicago Manual of Style (17th edition)