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Generation of Drug-loaded Echogenic Liposomes using Microfluidic Hydrodynamic Flow Focusing

Mukherjee, Prithiviraj

Abstract Details

2016, MS, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
This work describes development of a microfluidic system for the synthesis of echogenic liposomes (ELIP) loaded with the thrombolytic drug rt-PA (recombinant tissue plasminogen activator). ELIP are phospholipid vesicles with encapsulated microbubbles. Drugs, genes, or bioactive gases encapsulated in ELIP can be delivered to specific tissue targets using ultrasound activation. Microfluidic devices were fabricated in Polydimethylsiloxane (PDMS), using the standard soft lithography methods and were optimized for flow rates and gas pressures to generate echogenic liposomes in the right size range and with good repeatability. The liposomes were generated in the size range of 2-20 µm, using octafluoropropane (OFP) and octfluorocyclobutane (C4F8) gases as core. Fluorescence microscopy was used to visualize encapsulation of the water soluble rt-PA drug. In future work, these liposomes could be used in non-invasive ultrasound-mediated drug delivery, to affect thrombolysis.
Ian Papautsky, Ph.D. (Committee Chair)
Madhuvanthi A. Kandadai, Ph.D. (Committee Member)
Chong Ahn, Ph.D. (Committee Member)
Christy Holland, Ph.D. (Committee Member)
48 p.

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Citations

  • Mukherjee, P. (2016). Generation of Drug-loaded Echogenic Liposomes using Microfluidic Hydrodynamic Flow Focusing [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460731209

    APA Style (7th edition)

  • Mukherjee, Prithiviraj. Generation of Drug-loaded Echogenic Liposomes using Microfluidic Hydrodynamic Flow Focusing. 2016. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460731209.

    MLA Style (8th edition)

  • Mukherjee, Prithiviraj. "Generation of Drug-loaded Echogenic Liposomes using Microfluidic Hydrodynamic Flow Focusing." Master's thesis, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460731209

    Chicago Manual of Style (17th edition)