Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
20934.pdf (14.45 MB)
ETD Abstract Container
Abstract Header
Development of Multifunctional Nanoparticles: From Synthesis to Theranostic Applications
Author Info
Ozkaya Ahmadov, Tevhide
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1463130977
Abstract Details
Year and Degree
2016, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
Abstract
The objective of my research is to develop multifunctional nanoparticles for sensing and photodynamic therapy applications. Ethylenediaminetriacetic acid (EDTA)-functionalized silica nanoparticles were synthesized by microemulsion method. The EDTA groups on the nanoparticle surface have the role to chelate with metal ions to form paramagnetic nanoparticles in aqueous solution, which would reduce the relaxation rate of water protons. In this study, SiO2@TMS-EDTA@Fe
3+
NPs and SiO2@TMS-EDTA@Gd
3
NPs were used for detection of dopamine and phosphate ion, respectively. The results demonstrate that paramagnetic nanoparticles can be integrated into relaxation based detection schemes while avoiding the aggregation problem commonly associated with more widely used superparamagnetic nanoparticles. Lanthanide-based NaYF
4
:Yb
3+
,Tm
3+
upconversion nanoparticles were synthesized in the presence of polyacrylicacid (PAA) via solvothermal method. This is an one step synthesis method to get uniform, reproducible and biocompatible NaYF
4
:Yb,Tm upconversion nanoparticles with –COOH surface functional groups. In this study, we designed a ligase-assisted signal-amplifiable DNA biosensor based on NaYF
4
:Yb
3+
,Tm
3+
UCNPs with high sensitivity and specificity. Silver nanoparticles captured by mesoporous silica nanoparticles with photosensitizer (Ag@MS@HPIX) were synthesized using silver nitrate as the silver source, formaldehyde as the reducing agent, CTAB as the template/stabilizer, TEOS/TMS-EDTA as the silane source, sodium hydroxide as the catalyst, and HPIX as the loading photosensitizer. Ag@MS@HPIX NPs show strong enhanced singlet oxygen generation because of the strong resonance coupling between surface plasmon Ag nanoparticles and the photosensitizing molecules, consequently demonstrating highly efficient photodynamic inactivation (PDI) efficacy against both gram-positive and gram-negative bacteria. In this study, PDI efficacy of Ag@MS@HPIX NPs was tested against a multidrug-resistant strain of
Staphylococcus aureus.
Theranostic silver nanoparticles were synthesized via a new, robust, simple, and reproducible microwave-assisted method. The EDTA groups on the nanoparticle surface have the role to chelate with Gd
3+
ions to form paramagnetic nanoparticles in aqueous solution, which would reduce the relaxation rate of water protons. In addition, the surface of Ag@TMS-EDTA@Gd
3+
NPs has the potential to form a lanthanide-porphyrin complex, serving as photosensitizers in photodynamic therapy (PDT). This nanoplatform combines functions of magnetic resonance imaging (MRI) contrast agents and PDI agents in a single nanostructure as theranostics. In this study, we performed a systematic study of multifunctional Ag@TMS-EDTA@Gd
3+
@HPIX NPs to assess the PDI efficacy against the MRSA, which is a multidrug-resistant strain of
Staphylococcus aureus
. In summary, multifunctional nanoparticles, including silica, upconversion and silver nanoparticles were successfully synthesized and their potential applications in sensing and photodynamic therapy were explored.
Committee
Peng Zhang, Ph.D. (Committee Chair)
William Heineman, Ph.D. (Committee Member)
Allan Pinhas, Ph.D. (Committee Member)
Thomas Ridgway, Ph.D. (Committee Member)
Pages
97 p.
Subject Headings
Chemistry
Keywords
nanoparticles
;
magnetic relaxation
;
singlet oxygen enhancement
;
sensor
;
photodynamic therapy
;
MRSA
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Ozkaya Ahmadov, T. (2016).
Development of Multifunctional Nanoparticles: From Synthesis to Theranostic Applications
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1463130977
APA Style (7th edition)
Ozkaya Ahmadov, Tevhide.
Development of Multifunctional Nanoparticles: From Synthesis to Theranostic Applications.
2016. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1463130977.
MLA Style (8th edition)
Ozkaya Ahmadov, Tevhide. "Development of Multifunctional Nanoparticles: From Synthesis to Theranostic Applications." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1463130977
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
ucin1463130977
Download Count:
330
Copyright Info
© 2016, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.