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21044.pdf (2.54 MB)
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Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection
Author Info
Betz, Kristina J, B.A.
ORCID® Identifier
http://orcid.org/0000-0003-1305-0237
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062
Abstract Details
Year and Degree
2016, PhD, University of Cincinnati, Medicine: Immunology.
Abstract
IgA is the most abundant antibody in the human body, and has been shown to play diverse roles in the immune system ranging from homeostasis to protection from infection. To study this molecule further, we first investigated its dynamics in a murine weanling undernutrition model and its contribution to protection against rotavirus infection. Second, we used genetically modified mice to investigate intestinal barrier function and response to Salmonella typhimurium infection in the absence of IgA transport into the intestinal lumen. Vaccination against rotavirus in the context of protein-energy malnutrition revealed equal protection against rotavirus challenge as compared to well-nourished mice. Additionally, undernourished mice had an increase in serum IgA and a corresponding decrease in fecal IgA. Mice lacking intestinal IgA transport had mild physiological intestinal barrier dysfunction without a parallel increase in bacterial translocation. Surprisingly, these mice exhibited increased survival as compared to wildtype mice when challenged orally or intravenously with Salmonella typhimurium. These findings suggest that the importance of IgA is influenced by various outside factors, and the role for IgA within the immune system may be more nuanced than previously thought.
Committee
Sean Moore, M.S. M.D. (Committee Chair)
Theresa Alenghat, Ph.D. (Committee Member)
George Deepe, M.D. (Committee Member)
Simon Hogan, Ph.D. (Committee Member)
Kris Steinbrecher, Ph.D. (Committee Member)
Pages
167 p.
Subject Headings
Immunology
Keywords
IgA
;
undernutrition
;
Rotavirus
;
Salmonella
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Refworks
EndNote
RIS
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Citations
Betz, K. J. (2016).
Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection
[Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062
APA Style (7th edition)
Betz, Kristina.
Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection.
2016. University of Cincinnati, Doctoral dissertation.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062.
MLA Style (8th edition)
Betz, Kristina. "Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062
Chicago Manual of Style (17th edition)
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Document number:
ucin1467988062
Download Count:
289
Copyright Info
© 2016, some rights reserved.
Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection by Kristina J Betz B.A. is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.