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Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection

Betz, Kristina J, B.A.

Abstract Details

2016, PhD, University of Cincinnati, Medicine: Immunology.
IgA is the most abundant antibody in the human body, and has been shown to play diverse roles in the immune system ranging from homeostasis to protection from infection. To study this molecule further, we first investigated its dynamics in a murine weanling undernutrition model and its contribution to protection against rotavirus infection. Second, we used genetically modified mice to investigate intestinal barrier function and response to Salmonella typhimurium infection in the absence of IgA transport into the intestinal lumen. Vaccination against rotavirus in the context of protein-energy malnutrition revealed equal protection against rotavirus challenge as compared to well-nourished mice. Additionally, undernourished mice had an increase in serum IgA and a corresponding decrease in fecal IgA. Mice lacking intestinal IgA transport had mild physiological intestinal barrier dysfunction without a parallel increase in bacterial translocation. Surprisingly, these mice exhibited increased survival as compared to wildtype mice when challenged orally or intravenously with Salmonella typhimurium. These findings suggest that the importance of IgA is influenced by various outside factors, and the role for IgA within the immune system may be more nuanced than previously thought.
Sean Moore, M.S. M.D. (Committee Chair)
Theresa Alenghat, Ph.D. (Committee Member)
George Deepe, M.D. (Committee Member)
Simon Hogan, Ph.D. (Committee Member)
Kris Steinbrecher, Ph.D. (Committee Member)
167 p.

Recommended Citations

Citations

  • Betz, K. J. (2016). Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062

    APA Style (7th edition)

  • Betz, Kristina. Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062.

    MLA Style (8th edition)

  • Betz, Kristina. "Immunoglobulin A Dynamics in Rotavirus and S. typhimurium Infection." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1467988062

    Chicago Manual of Style (17th edition)