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Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring

Kinder, Jeremy M.
http://orcid.org/0000-0001-5145-1344
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816425343745

Abstract Details

2016, PhD, University of Cincinnati, Medicine: Immunology.
Our genetic makeup is equally inherited from our mother and father through classical Mendelian genetics. However, each individual is constitutively chimeric, containing genetically foreign cells vertically transferred from their mothers during in utero development. These rare maternal microchimeric maternal cells have been identified to persist many years after birth and across a wide range of tissues demonstrating remarkable immune tolerance to our mothers persists in us long after we are born. Reciprocally during pregnancy, mothers also receive a transfer of fetal cells that persist after parturition. We have shown that transfer of these genetically foreign cells during gestation is not accidental, but instead these cells are intentionally retained to promote reproductive fitness in subsequent pregnancies. Herein, we will explore the teleological and immunological implications of the long-term retention these genetically foreign cells.
Sing Sing Way, Ph.D. (Committee Chair)
David Hildeman, Ph.D. (Committee Member)
Jonathan Katz, Ph.D. (Committee Member)
Aimen Shaaban, M.D. (Committee Member)
Harinder Singh (Committee Member)
227 p.
Immunology
Maternal microchimeric cells; Fetal microchimeric cells; Reproductive Immunology; Regulatory T Cells

Recommended Citations

Citations

  • Kinder, J. M. (2016). Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816425343745

    APA Style (7th edition)

  • Kinder, Jeremy. Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring. 2016. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816425343745.

    MLA Style (8th edition)

  • Kinder, Jeremy. "Reproductive Benefits Conferred by Genetically Foreign Cells that Persist in Mothers and Offspring." Doctoral dissertation, University of Cincinnati, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479816425343745

    Chicago Manual of Style (17th edition)

ucin1479816425343745
288
© 2016, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.