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Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver disease

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2017, PhD, University of Cincinnati, Arts and Sciences: Anthropology.
Obesity and its numerous co-morbid diseases are some of the most common and expensive health conditions currently facing the developed world. Nonalcoholic fatty liver disease (NAFLD) is a complex, progressive, multi-factorial condition that is characterized by the benign accumulation of fatty acids within the liver, also known as steatosis. In many cases, NAFLD may progress to nonalcoholic steatohepatitis (NASH), which is defined as steatosis along with inflammation and fibrosis. NASH can develop into cirrhosis, a condition characterized by the replacement of healthy hepatic tissue with nonfunctional scar tissue. Advanced cirrhosis is directly linked to the development of hepatocellular carcinoma (HCC), which requires an immediate liver transplant. Because the progression of NAFLD requires such intensive medical intervention, the diagnosis and treatment of NAFLD is critical. Numerous previous studies have identified potential genetic risk factors for development of NAFLD. However, the exact mechanism within the context of lipid metabolism has been inadequately explored. Low-density lipoprotein receptor related protein 1 (LRP1), a receptor for chylomicron remnants in the liver, has previously been associated with a number of serious, progressive diseases, but has not been implicated specifically in liver disease.
David Hui, Ph.D. (Committee Chair)
Burns Blaxall, Ph.D. (Committee Member)
Evangelia Kranias, Ph.D. (Committee Member)
Jo Schultz, Ph.D. (Committee Member)
113 p.

Recommended Citations

Citations

  • Hamlin, A. (2017). Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver disease [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490698940398626

    APA Style (7th edition)

  • Hamlin, Allyson. Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver disease. 2017. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490698940398626.

    MLA Style (8th edition)

  • Hamlin, Allyson. "Hepatic Lrp1 deficiency and the development of nonalcoholic fatty liver disease." Doctoral dissertation, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490698940398626

    Chicago Manual of Style (17th edition)