Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


22473.pdf (4.71 MB)

ETD Abstract Container

Abstract Header

Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer

Intarakumhaeng, Rattikorn
http://orcid.org/0000-0002-8960-9570
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491316295006087

Abstract Details

2017, PhD, University of Cincinnati, Pharmacy: Pharmaceutical Sciences/Biopharmaceutics.
Skin has been the focus of research as a site of local and systemic drug delivery due to its advantages over other routes of drug delivery. However, the determining factors that could affect the transport of compounds through and into the skin are still unclear. The main purpose of the present dissertation was to understand the determinants affecting skin permeation, including the influence of solvents and solute physicochemical properties on skin permeation and the effects of a penetration enhancer on the skin penetration of highly lipophilic permeants. The objective of Chapter 3 was to examine the effects of solvents upon the deposition of a model solute, corticosterone (CS) in the stratum corneum (SC) that could influence skin absorption of the solute after topical application. The solvents used in the study had different evaporation rates that were expected to impact skin deposition of CS and its absorption across skin. The results show no correlation between the rate of CS absorption and the rate of solvent evaporation with volatile solvents, suggesting no difference in solvent-induced deposition of CS in the SC. The results of these volatile solvents were different from those of slower evaporating solvents, that a relationship between permeant absorption and solvent evaporation rate was observed. The study performed in Chapter 4 was a continuing effort to investigate the effects of solvents on skin absorption of lipophilic and polar solutes and examine the relationships between solute physicochemical properties and skin absorption of these solutes. Skin permeation experiments under the finite and infinite dose conditions were conducted with model solutes and selected solvents. Except for urea, the skin permeation results of the solutes under the finite dose condition of the volatile solvents were in general agreement with the permeability coefficients obtained under the infinite dose condition. In Chapter 5, we probed the mechanism of the observed high finite dose skin permeation of urea, in contrast to its permeability coefficient. A small hydrophilic solute ethylene glycol (EG) with molecular weight similar to urea was studied for comparison. The results suggest that urea did not have penetration enhancing activity to enhance its permeation across skin under the finite dosing. Tape stripping results are consistent with skin permeation mechanism of solute deposition and diffusion. We hypothesized that the skin permeation behavior of urea could be attributed to the small molecular size of urea. Under the finite dose conditions examined in this study, solutes with molecular sizes similar to or less than urea and EG could lead to high percent of skin absorption independent of solute lipophilicity. Chapter 6 aimed to examine the skin penetration of petrolatum and soybean oil after skin application with and without a penetration enhancer, glyceryl monooleate (GlyMOle). GlyMOle was found to enhance the penetration of petrolatum into the split-thickness skin and an active dose-dependent effect was observed. However, GlyMOle did not enhance the penetration of soybean oil in any conditions. The results of this study suggest that GlyMOle was a penetration enhancer for petrolatum under the studied condition.
Kevin Li, Ph.D. (Committee Chair)
Gerald Kasting, Ph.D. (Committee Member)
Harshita Kumari (Committee Member)
Q. Ching Stella, Ph.D. (Committee Member)
R. Randall Wickett, Ph.D. (Committee Member)
174 p.
Pharmaceuticals
percutaneous absorption; solvent effects; solute physicochemical properties; penetration enhancer; topical skin delivery; skin

Recommended Citations

Citations

  • Intarakumhaeng, R. (2017). Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491316295006087

    APA Style (7th edition)

  • Intarakumhaeng, Rattikorn. Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer. 2017. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491316295006087.

    MLA Style (8th edition)

  • Intarakumhaeng, Rattikorn. "Factors Influencing Percutaneous Absorption: Effects of Solvents, Solute Physicochemical Properties, and Penetration Enhancer." Doctoral dissertation, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491316295006087

    Chicago Manual of Style (17th edition)

ucin1491316295006087
399
© 2017, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.