Asthma is a chronic obstructive lung disease that affects nearly 19 million adults in the United States (CDC, 2015). If not well controlled through medical intervention, asthma can result in significant rates of morbidity and mortality. One important contributor to the negative impact of asthma is the presence of psychopathology, particularly panic psychopathology (Goodwin et al., 2010; McCauley et al., 2007). In order to better understand the association between asthma and panic psychopathology, recent literature has begun examining the role of anxiety-related cognitive risk factors in asthma outcomes. This work has primarily focused on the cognitive risk factor of anxiety sensitivity (AS; fear of arousal-related sensations; McNally, 2002) and found that higher levels of anxiety sensitivity are predictive of poorer asthma outcomes (Avallone et al., 2012; McLeish et al., 2011; McLeish et al. 2016). An important next step in this area of work is to explore associations between asthma and other anxiety-related cognitive risk factors. One such factor to examine in this regard is distress tolerance (DT), defined as an individual’s perceived or behavioral capacity to withstand distress related to aversive affective states (Simons & Gaher, 2005; Zvolensky et al., 2011). Indeed, low DT is associated with increased risk for anxiety disorders as well as greater AS (Keough et al., 2010). Therefore, the aim of the current study was to examine the unique predictive ability of self-reported global and behavioral distress tolerance, as well as tolerance of fear and anxiety in terms of asthma control, asthma-related quality of life and lung function among non-smoking adults with current asthma. (n = 61; 61.9% female, 54.8% African-American, Mage = 34.72, SD = 13.58). Results indicated that, after controlling for the effects of age, race, and anxiety sensitivity, greater self-reported DT significantly predicted better lung function (ß = .39, t = 2.80, p < .01), asthma control (ß = .31, t = 2.77, p < .01), and asthma quality of life (ß = .27, t = 2.53, p < .05). Behavioral DT did not significantly predict asthma outcomes. Greater self-reported tolerance of fear significantly predicted better lung function, (ß = .30, t = 2.28, p < .05), asthma control (ß = .28, t = 2.70, p < .01), and quality of life (ß = .30, t = 3.23, p < .01). Additionally, tolerance of anxiety also significantly predicted better lung function (ß = .33, t = 2.55, p < .01), asthma control ß = .23, t = 2.08, p < .05), and quality of life (ß = .28, t = 2.88, p < .01). These findings suggest that developing interventions targeting DT may be an effective way to improve asthma outcomes.