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Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review

Tommie, Jessica
http://orcid.org/0000-0001-6727-8988
http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945

Abstract Details

2017, MS, University of Cincinnati, Allied Health Sciences: Nutrition.
Background: The association between vitamin D status and breast cancer risk is equivocal. No systematic reviews or meta-analyses have examined this association stratified by receptor status. Our objective is to conduct a systematic review to answer the question, “Is there a relationship between lower serum/plasma vitamin D levels and increased risk of triple negative breast cancer (TNBC) specifically?” Methods: We system searched Embase and PubMed databases for published original research studies examining the risk of a breast cancer diagnosis according to vitamin D status. We excluded studies that did not provide risk estimates stratified by receptor status. Results: Fourteen studies met our criteria, including case-control, nested case-control, and case-series studies, reflecting the cumulative results of 13,135 breast cancer cases. When grouped by relevancy to TNBC, the proportion of analyses across all study types showing a significant association between vitamin D status and breast cancer diagnosis was 37% for non-TNBC analyses, 48% for analyses that included some TNBC cases, and 88% for TNBC analyses. Conclusions: Our results suggest that low vitamin D status may particularly increase the risk of TNBC, although more research is needed to determine if this association is causative. Women should be routinely screened for 25(OH)D deficiency.
Laurie Nommsen-Rivers, Ph.D. (Committee Chair)
Susan Pinney, Ph.D. (Committee Member)
49 p.
Nutrition
Breast cancer; Vitamin D; 25-hydroxyvitamin D; Triple negative breast cancer

Recommended Citations

Citations

  • Tommie, J. (2017). Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945

    APA Style (7th edition)

  • Tommie, Jessica. Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review. 2017. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945.

    MLA Style (8th edition)

  • Tommie, Jessica. "Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review." Master's thesis, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945

    Chicago Manual of Style (17th edition)

ucin150480332518945
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© 2017, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.