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Extra pulmonary Nontuberculous Mycobacterial Infections 16 Year Retrospective Analysis at an Academic Institution in Cincinnati Ohio

Afshan, Kiran
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504869625635459

Abstract Details

2017, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Background: Nontuberculous mycobacterial infections (NTM), once considered a rare cause of human disease, are now increasingly recognized in clinical practice. We have sought to identify clinical and demographic characteristics of the extra-pulmonary NTM infections presenting at our institution during 2000-2015. Methods: Records of patient with culture proven extra-pulmonary NTM infections were reviewed. Demographic information, clinical and microbiologic characteristics and treatment outcomes were captured. Results: 58 cases of extra-pulmonary NTM infections identified were classified into cutaneous 9 (15.52%), soft tissue 38 (65.52%), osteo-articular 9 (15.52%) and disseminated infections 2 (3.45%). 52% of the cases were male. Median age at diagnosis was 52years. All cases were diagnosed based on culture positivity. Among identified mycobacterial species, rapid growing mycobacteria constituted 79% of all cases with following distribution: Mycobacterium fortuitum complex 28 (48.28%), Mycobacterium abscessus/chelonae complex 15 (25.86%), Mycobacterium avium intracellulare complex 3 (5.17%), Mycobacterium marinum 3 (5.17%), Mycobacterium gordonae 2 (3.45%), and one case each of Mycobacterium arupense, Mycobacterium goodii, Mycobacterium haemophilum, Mycobacterium kansasii, Mycobacterium mageritense, Mycobacterium simiae and Mycobacterium wolinskyi, [combined 7(12.04%)]. Overall cure rate was 84.6%. Conclusion: Health care professionals should be aware of increasing significance of the extra-pulmonary NTM infections and should utilize appropriate diagnostic modalities to ensure proper identification and improve treatment outcomes. Key Words: Nontuberculous mycobacteria, extra-pulmonary infections, M fortuitum, M abscessus/chelonae, immunocompromised conditions, treatment outcome.
Erin Haynes, Dr.P.H. (Committee Chair)
Lisa Haglund, M.D. (Committee Member)
Roman Jandarov (Committee Member)
20 p.
Surgery
Nontuberculous mycobacteria; Extra pulmonary infections; M fortuitum; M abscessus chelonae; immunocompromised conditions; treatment outcome

Recommended Citations

Citations

  • Afshan, K. (2017). Extra pulmonary Nontuberculous Mycobacterial Infections 16 Year Retrospective Analysis at an Academic Institution in Cincinnati Ohio [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504869625635459

    APA Style (7th edition)

  • Afshan, Kiran. Extra pulmonary Nontuberculous Mycobacterial Infections 16 Year Retrospective Analysis at an Academic Institution in Cincinnati Ohio. 2017. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504869625635459.

    MLA Style (8th edition)

  • Afshan, Kiran. "Extra pulmonary Nontuberculous Mycobacterial Infections 16 Year Retrospective Analysis at an Academic Institution in Cincinnati Ohio." Master's thesis, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504869625635459

    Chicago Manual of Style (17th edition)

ucin1504869625635459
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© 2017, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.