Skip to Main Content
Frequently Asked Questions
Submit an ETD
Global Search Box
Need Help?
Keyword Search
Participating Institutions
Advanced Search
School Logo
Files
File List
27949.pdf (902.09 KB)
ETD Abstract Container
Abstract Header
Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus
Author Info
Holland, Michael J
ORCID® Identifier
http://orcid.org/0000-0002-5377-3002
Permalink:
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1527606864223975
Abstract Details
Year and Degree
2017, MS, University of Cincinnati, Medicine: Clinical and Translational Research.
Abstract
Objectives: To describe the frequency and distribution of disease damage in childhood-onset systemic lupus erythematosus (cSLE) as measured by the 41-item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI’s relationship to damage severity. Methods: SDI item and summary-scores from 1,048 cSLE patients in three existing cohorts were included. In one cohort of 559 patients, treating physicians also rated damage severity, using a visual analog scale (MD-VASdamage). Damage item frequency was determined, and the association between SDI scores and available MD-VASdamage ratings measured. Finally, an international consensus conference, utilizing nominal group technique, considered the SDI’s capture of cSLE damage severity. Results: After a mean disease duration of 3.8 years, some damage (SDI summary-score > 0) was present in 44.2% (463/1048) of patients, with a maximum SDI summary-score of 14. The most common SDI items were: proteinuria, alopecia, cognitive impairment, and musculoskeletal atrophy. In those patients with MD-VASdamage ratings and known damage (SDI > 0), there was a moderately strong association between SDI summary-scores and MD-VASdamage (rSpearman = 0.49; p<0.0001). Mixed effect analysis revealed that only four SDI items, all occurring in <2% of patients, were significantly associated with MD-VASdamage. After consideration of these results, unanimous consensus was achieved that a new instrument or approach is needed to measure cSLE damage severity. Conclusion: Despite the relatively short mean disease duration, damage measured by the SDI was common in cSLE. Physician-perceived damage severity was not well captured by SDI summary-scores, and improved measures are needed.
Committee
Erin Haynes, Dr.P.H. (Committee Chair)
Hermine Brunner, M.D. (Committee Member)
Richard Ittenbach (Committee Member)
Daniel Lovell, M.D. (Committee Member)
Esi Morgan (Committee Member)
Pages
27 p.
Subject Headings
Surgery
Keywords
Systemic Lupus Erythematosus
;
Damage
;
Measurement
;
Pediatric
Recommended Citations
Refworks
EndNote
RIS
Mendeley
Citations
Holland, M. J. (2017).
Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus
[Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1527606864223975
APA Style (7th edition)
Holland, Michael.
Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus.
2017. University of Cincinnati, Master's thesis.
OhioLINK Electronic Theses and Dissertations Center
, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1527606864223975.
MLA Style (8th edition)
Holland, Michael. "Measuring Disease Damage and its Severity in Childhood-Onset Systemic Lupus Erythematosus." Master's thesis, University of Cincinnati, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1527606864223975
Chicago Manual of Style (17th edition)
Abstract Footer
Document number:
ucin1527606864223975
Download Count:
586
Copyright Info
© 2017, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.