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Modeling of scaffold for cleft-repairing through finite element analysis

Huang, Xu
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530273324567169

Abstract Details

2018, MS, University of Cincinnati, Engineering and Applied Science: Materials Science.
Children with unilateral alveolar clefts may develop complications, including infection at the secondary surgical site, relapse, and facial asymmetry due to unpredictable post-surgical growth. Because the mineralization rate of osteoblasts is sensitive to strain distributions in the skull, asymmetric strain distribution may lead to unbalanced bone growth. Recently, clinical trials have developed scaffolds with certain porosity to help the growth of the new bones and to alleviate these risks and improve bone healing. Thus, the strain inside the scaffold also influences de novo bone deposition and resorption. The aim of this study is to develop finite element models and conduct detailed computational analyses to decrease experimental animals, we will also explore how scaffold design changes strain distributions in cleft pig skulls. First, we construct two three-dimensional (3D) pig skull models and two different architected scaffolds. Then we perform finite element analysis (FEA) to find ways to decrease the asymmetric strain distributions produced by scaffolds used in the surgery. Finally, these results showed that the asymmetric strain distribution can be effectively reduced by use of different types of scaffolds. We also found that scaffold applied to reconstruct alveolar cleft can be 3D-printed with low stiffness biodegradable material, which also includes significant porosity to facilitate cell infiltration. These results support that FEA can be an effective computational tool to design suitable scaffold for cleft-repairing and predict detailed strain distributions. FEA is beneficial to prepare biodegradable scaffold for in vivo testing and an excellent assistant to surgical operations.
Gui-Rong Liu, Ph.D. (Committee Chair)
Yao Fu (Committee Member)
Jude Iroh, Ph.D. (Committee Member)
49 p.
Materials Science
Cleft repairing; Finite element; Biodegradable material; Scaffold; Skull strain

Recommended Citations

Citations

  • Huang, X. (2018). Modeling of scaffold for cleft-repairing through finite element analysis [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530273324567169

    APA Style (7th edition)

  • Huang, Xu. Modeling of scaffold for cleft-repairing through finite element analysis. 2018. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530273324567169.

    MLA Style (8th edition)

  • Huang, Xu. "Modeling of scaffold for cleft-repairing through finite element analysis." Master's thesis, University of Cincinnati, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1530273324567169

    Chicago Manual of Style (17th edition)

ucin1530273324567169
289
© 2018, some rights reserved.Creative Commons License Modeling of scaffold for cleft-repairing through finite element analysis by Xu Huang is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.