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Open Nanofluidic Films with Rapid Transport and No Analyte Loss for Ultra-Low Sample Volumes

Twine, Nicholas B
http://orcid.org/0000-0002-2572-158X
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535633706613122

Abstract Details

2018, MS, University of Cincinnati, Engineering and Applied Science: Electrical Engineering.
Moving to ultra-low (<100 nL) sample volumes presents numerous challenges, many of which can be resolved by implementation of open nanofluidic films. These nanofluidic films are fabricated using a hexagonal network of gold-coated open microchannels which capture all of the following innovative advantages: (1) sample volumes of <100 nL/cm2; (2) zero analyte exchange and loss with the film materials; (3) rapid and omni-directional wicking transport of >500 nL/min per square of film; (4) ultra-simple roll-to-roll fabrication; (5) stable and bio-compatible super-hydrophilicity for weeks in air by peptide surface modification. Validation includes both detailed in-vitro characterization and in-vivo validation with sweat transport from the human skin. Sampling times (skin-to-sensor) of <3 minutes were achieved, setting new benchmarks for the field of wearable sweat sensing. This work addresses significant challenges for sweat biosensing, or for any other nano-liter regime (<100 nL) fluid sampling and sensing application.
Jason Heikenfeld, Ph.D. (Committee Chair)
Chong Ahn, Ph.D. (Committee Member)
Andrew Steckl, Ph.D. (Committee Member)
35 p.
Engineering
Microfluidics; Sweat Sensing; Biotechnology; Nanoliter; Electrochemistry; Superhydrophilic

Recommended Citations

Citations

  • Twine, N. B. (2018). Open Nanofluidic Films with Rapid Transport and No Analyte Loss for Ultra-Low Sample Volumes [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535633706613122

    APA Style (7th edition)

  • Twine, Nicholas. Open Nanofluidic Films with Rapid Transport and No Analyte Loss for Ultra-Low Sample Volumes. 2018. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535633706613122.

    MLA Style (8th edition)

  • Twine, Nicholas. "Open Nanofluidic Films with Rapid Transport and No Analyte Loss for Ultra-Low Sample Volumes." Master's thesis, University of Cincinnati, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535633706613122

    Chicago Manual of Style (17th edition)

ucin1535633706613122
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© 2018, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.