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Prolonged Biofluid Access by Iontophoretic Delivery of Slowly Metabolized Cholinergic Agents and Integration into a Wearable Device

Simmers, Phillip Charles
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535634635926094

Abstract Details

2018, PhD, University of Cincinnati, Engineering and Applied Science: Biomedical Engineering.
Despite many of the new innovative methods and devices designed that display the superior nature of sweat ergonomics, sweat is still an underutilized biofluid compared to the more orthodox biofluids blood, urine, and saliva. With new information surfacing about the capabilities of sweat biosensing more hope can be invested that sweat could fill the void of a truly non-invasive biofluid capable of continuous biomonitoring. However, similar issues or challenges with sweat have been chronicled that keep researchers from reaching the pinnacle of unhindered continuous biomonitoring. The recent issues of low sample volumes (nL to µL), skin surface contaminants, robustness of commercially available sensors, dilution of large analytes have built a daunting task for researches pursuing sweat. Additionally, these challenges become much more arduous when sedentary users are considered (low to no sweat production). This dissertation looks to address many of these unresolved challenges through innovative means. Described within this dissertation are methods aimed at artificially stimulating natural sweating events and their incorporation into wearable devices aimed for long term sweat-based biosensing. This includes an in-depth analysis of nicotinic and muscarinic agonists utilized for the establishment of prolonged sweating events, reduction of iontophoretic stress, and isolation of stimulant drug reservoir to control dosing and eliminate stimulant source and sweat sample contamination. Utilizing this information, a method which incorporates preexisting sweat management and sensing systems with a stimulation source is also presented. This dissertation actively characterizes complete sweating events and presents an advanced integrated device design and functionality. These entire sweating events paired with reductions in iontophoretic stresses provides the opportunity for maintaining a consistent flow rate of sweat for prolonged periods of time, which is important for many biomarkers that are affected by sweat flow rates. Finally, this dissertation presents a truly integrated sweat stimulation, sweat management, and biomarker sensing modalities that unlocks the possibility of monitoring individuals at rest. This is done in a cost-effective manner while addressing many deficiencies attributed to previous devices. Due to the nature of the novel integrated design a wider array of sensing components (aptamer, ionic selective electrodes, etc.) are likely compatible which would increase the devices potential capabilities.
Jason Heikenfeld, Ph.D. (Committee Chair)
Kevin Li, Ph.D. (Committee Member)
Mary Beth Privitera, M.Des. (Committee Member)
Jason Shearn, Ph.D. (Committee Member)
128 p.
Biomedical Research
Sweat Sensing; Sweat Stimulation; Controlled drug delivery; Integrated sweat sensing patch; Prolonged stimulated sweat

Recommended Citations

Citations

  • Simmers, P. C. (2018). Prolonged Biofluid Access by Iontophoretic Delivery of Slowly Metabolized Cholinergic Agents and Integration into a Wearable Device [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535634635926094

    APA Style (7th edition)

  • Simmers, Phillip. Prolonged Biofluid Access by Iontophoretic Delivery of Slowly Metabolized Cholinergic Agents and Integration into a Wearable Device. 2018. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535634635926094.

    MLA Style (8th edition)

  • Simmers, Phillip. "Prolonged Biofluid Access by Iontophoretic Delivery of Slowly Metabolized Cholinergic Agents and Integration into a Wearable Device." Doctoral dissertation, University of Cincinnati, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535634635926094

    Chicago Manual of Style (17th edition)

ucin1535634635926094
546
© 2018, some rights reserved.Creative Commons License Prolonged Biofluid Access by Iontophoretic Delivery of Slowly Metabolized Cholinergic Agents and Integration into a Wearable Device by Phillip Charles Simmers is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.