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Quantitative Analysis of Phase-Transition Process of Light-Activatable Theranostic Agents by Pulsed Laser

Zhang, Zhe
http://orcid.org/0000-0003-3249-0465
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535705361083778

Abstract Details

2018, MS, University of Cincinnati, Engineering and Applied Science: Chemical Engineering.
In this study, we focused on the quantitative analysis of the phase-transition process of our developed nanodroplets. To begin with, our nanodroplets have gold nanorods coated on the shells. Upon light irradiation, the gold nanorods can absorb photons and get heated due to plasmonic photothermal effect and lead to the heating of the nanodroplets, which will undergo phase-transition to micron-sized bubbles. In other words, our nanodroplets are light activatable for drug release in a controlled manner. Second, when the nanodroplets undergo phase-transition to micron-sized bubbles, the ultrasound imaging contrast can be dramatically increased, so ultrasound imaging can be employed as the tool to observe the phase-transition process. This characteristic renders our nanodroplets theranostic. After being able to observe the phase-transition, we then analyzed the amount of drug released from the nanodroplets upon the irradiation of pulsed laser for a period of time by analyzing the brightness variance of the ultrasound images. The result obtained did show a correlation of lasing time and the amount of drug released from phase-transition. Perfluorocarbon (PFC) is the phase change agent used to synthesize our nanodroplets, and we tried two different PFC-- perfluoro pentane (PF5) and perfluoro hexane (PF6). Due to the boiling point difference of PF5 and PF6, we noticed that sometimes phase-transition does not happen to PF6 nanodroplets, where PF5 nanodroplets did undergo phase change under the same condition. Thus, we continued the study with the goal of studying the kinetics of phase transition and determining the power or temperature threshold required to trigger the phase-transition of PF5 and PF6 nanodroplets by employing mathematical models. Although we were not able to obtain a specific temperature by using the model we adopted, we were able to make a list of the potential temperature by varying parameters such as beam area and the percentage of phase-transition. In conclusion, we have developed nanodroplets that can be triggered by external light in a precise controlled manner by varying lase irradiation duration, and we were able to set the boundaries of the phase-transition temperature from the mathematical model and experiment data obtained.
Yoonjee Park, Ph.D. (Committee Chair)
Junhang Dong, Ph.D. (Committee Member)
Vesselin Shanov, Ph.D. (Committee Member)
36 p.
Chemical Engineering
phase transition; Arrhenius equation; kinetic study; perfluorocarbon; nanodroplets; pulsed laser

Recommended Citations

Citations

  • Zhang, Z. (2018). Quantitative Analysis of Phase-Transition Process of Light-Activatable Theranostic Agents by Pulsed Laser [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535705361083778

    APA Style (7th edition)

  • Zhang, Zhe. Quantitative Analysis of Phase-Transition Process of Light-Activatable Theranostic Agents by Pulsed Laser. 2018. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535705361083778.

    MLA Style (8th edition)

  • Zhang, Zhe. "Quantitative Analysis of Phase-Transition Process of Light-Activatable Theranostic Agents by Pulsed Laser." Master's thesis, University of Cincinnati, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535705361083778

    Chicago Manual of Style (17th edition)

ucin1535705361083778
220
© 2018, some rights reserved.Creative Commons License Quantitative Analysis of Phase-Transition Process of Light-Activatable Theranostic Agents by Pulsed Laser by Zhe Zhang is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. Based on a work at etd.ohiolink.edu.
This open access ETD is published by University of Cincinnati and OhioLINK.