Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List


34160.pdf (7.15 MB)

ETD Abstract Container

Abstract Header

Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics

Unser, Sarah A
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383

Abstract Details

2019, PhD, University of Cincinnati, Arts and Sciences: Chemistry.
This thesis contains work that has been done in order to improve the sensitivity and selectivity of localized surface plasmon resonance sensors, specifically in regards to medical and point-of-care diagnostics. For centuries the vivid optical properties of gold nanoparticles have captured the attention of both artists and scientists. Today, due to the bold colorimetric properties that are highly tunable, plasmonic nanoparticles have been key to their widespread popularity and incorporation into medical diagnostics. As diagnostics become more readily available for self-monitoring of human health, it is imperative that new devices are produced that are highly accurate, precise, and affordable for consumer use. Applying the colorimetric properties of plasmonic nanoparticles, their colorimetric readout helps create a response that is either a simple yes or no, or a quantitative colorimetric readout. The contents of this thesis highlight efforts to enhance the surface chemistry to improve the sensitivity of nanoparticle substrates for improved detection of health relevant biomolecules. In addition, integration of these nanoparticles into extracellular matrix and lipid membrane systems help improve the selectivity of these model schemes. These strategies applied in this thesis are aimed toward improving medical diagnostics to make them affordable for point-of-care scenarios to improve the quality of human health.
Laura Sagle, Ph.D. (Committee Chair)
Ruxandra Dima, Ph.D. (Committee Member)
Patrick Limbach, Ph.D. (Committee Member)
111 p.
Chemistry
Localized Surface Plasmon Resonance; Biosensors; Point-of-Care; Nanoparticles; Colorimetric Sensing; Diagnostics

Recommended Citations

Citations

  • Unser, S. A. (2019). Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383

    APA Style (7th edition)

  • Unser, Sarah. Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics. 2019. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383.

    MLA Style (8th edition)

  • Unser, Sarah. "Improving the Sensitivity and Selectivity of Localized Surface Plasmon Resonance Biosensors Toward Novel Point-of-Care Diagnostics." Doctoral dissertation, University of Cincinnati, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1561997005551383

    Chicago Manual of Style (17th edition)

ucin1561997005551383
454
© 2019, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.