Experiences during childhood play a crucial role in adolescents’ health outcomes. Previous research has documented the negative impact of Adverse Childhood Experiences (ACEs) on adolescents’ physical health, mental health and health risk behaviors (Bielas et al., 2016; Brown & Shillington, 2017; Isohookana et al., 2016). Although Latino adolescents may experience a higher prevalence of ACEs (Llabre et al., 2017), they have been largely overlooked in the research literature. Not all adolescents who experience adversity develop negative outcomes. Previous research has found emotion regulation, religious meaning-making, self-efficacy, locus of control, purpose, community support, family cohesion, and social support to promote resilience among individuals who experience adversity (Bellis et al., 2017; Cardoso & Thompson, 2010; Culpin, Stapinski, Miles, Araya & Joinson, 2015; Day & Kearney, 2016; Hamby, Grych & Banyard, 2018; Roh et al., 2015; Schweizer et al., 2016). Despite this, ACEs research has focused on negative outcomes instead of identifying protective factors that may help adolescents build resilience. In order to address these gaps, the present study sought to (1) determine the relation between ACEs and Latino adolescents’ subjective well-being (SWB) and (2) identify protective factors that could moderate that relationship. Eighty-eight Latino adolescents completed measures of ACEs, SWB, emotion regulation, religious meaning-making, self-efficacy, locus of control, purpose, community support, family cohesion and social support. Results suggest that the more ACEs adolescents experienced, the lower their SWB. Moreover, external locus of control, internal locus of control, family cohesion and purpose moderated the association between ACEs and SWB. The results suggest that helping Latino adolescents build a high sense of purpose, a high family cohesion, a low external locus of control and a high internal locus of control can promote a higher SWB despite experiencing ACEs.