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Association of dietary advanced glycation end products (AGEs) with inflammation and arterial stiffness in youth with type I diabetes

Stucke, Dea
http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592135011714719

Abstract Details

2020, MS, University of Cincinnati, Allied Health Sciences: Nutrition.
Background: Excessive intake of dietary Advanced Glycation End Products (dAGEs) or conditions that accelerate endogenous AGE formation, such as hyperglycemia, can promote oxidative stress and inflammation by cross-linking with body proteins and altering their structure and function. Several small-scale studies suggest an association between AGEs and inflammation and vascular dysfunction in individuals with diabetes, however, these relationships have not been examined in a large, diverse sample of youth with type 1 diabetes (T1D). Purpose: To determine the association between dAGEs and markers of inflammation and arterial stiffness in a diverse sample of youth with T1D from the multi-center SEARCH for Diabetes in Youth study. Methods: Children and adolescents from the SEARCH for Diabetes in Youth Study, ages 10-19 years, with T1D who had completed a demographics and food frequency questionnaire (FFQ) had measures of inflammation (IL-6, C-reactive protein, fibrinogen) and arterial stiffness. Measures of arterial stiffness included pulse wave velocity from carotid to the femoral artery (PWVcf), from the carotid to the radial artery (PWVcr) and from the femoral artery to the foot (PWVfft). Dietary AGE intake was determined by matching AGE values in foods reported by Uribarri et al. (1) to the FFQ foods and calculating daily AGE in kU/day. Clinical measures included BMI z-score, HbA1c at visit, systolic and diastolic blood pressure, mean arterial blood pressure, heart rate, and lipid profile. Associations between dAGE, inflammation and arterial stiffness measures were determined by multiple regression analysis adjusting for demographic and clinical measures. Results: From our sample of 1,623 TID youth, average dAGE intake was 17,704 kU/day and plasma AGE was 27.2 ng/mL. Positive correlations were found between dAGEs and plasma AGEs, age, HbA1c, systolic blood pressure, macronutrients, energy, PWVcr and PWVfft. Negative correlations were found between dAGEs and BMI z-score, HDL-C, fibrinogen and CRP. Many of these associations were also observed when examining dAGE by quartile of intake. Linear regression models showed a positive association between dAGE and PWVcr (p=0.0347) after adjusting for demographic factors, HbA1c, insulin regimen and diabetes duration, lipid profile, BMI z-score, blood pressure, physical activity and energy. A trend for a positive association was also observed between dAGE and IL-6 (p=0.3083) after adjustment for these same confounders. Conclusion: Findings from this study suggest a relationship between increased dietary intake of AGEs and arterial stiffness, and potentially inflammation. Moderating intake of AGEs may therefore be one way to reduce two important risk factors for CVD in youth with T1D. More research is warranted to examine these relationships further.
Sarah Couch, Ph.D. (Committee Chair)
Abigail Peairs, Ph.D. (Committee Member)
39 p.
Nutrition
Advanced Glycation End Products; Type I Diabetes; Pulse Wave Velocity; Arterial Stiffness; Inflammation; AGE

Recommended Citations

Citations

  • Stucke, D. (2020). Association of dietary advanced glycation end products (AGEs) with inflammation and arterial stiffness in youth with type I diabetes [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592135011714719

    APA Style (7th edition)

  • Stucke, Dea. Association of dietary advanced glycation end products (AGEs) with inflammation and arterial stiffness in youth with type I diabetes. 2020. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592135011714719.

    MLA Style (8th edition)

  • Stucke, Dea. "Association of dietary advanced glycation end products (AGEs) with inflammation and arterial stiffness in youth with type I diabetes." Master's thesis, University of Cincinnati, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592135011714719

    Chicago Manual of Style (17th edition)

ucin1592135011714719
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This open access ETD is published by University of Cincinnati and OhioLINK.