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Comparison of Selected Clinical Laboratory Tests on Adult Participants of the Fernald Medical Monitoring Program (FMMP), from the First Medical Examination from 1991 to 1994, Using the Third National Health and Nutrition Examination Survey (NHANES III) co

Brannen, Donald E
http://rave.ohiolink.edu/etdc/view?acc_num=ucin976116589

Abstract Details

2000, MS, University of Cincinnati, Medicine : Environmental Health Sciences.
Introduction: The objective of this cross sectional study was to determine if participants of the Fernald Medical Monitoring Program (FMMP) had abnormal laboratory values of outcome measures (AST, ALT, RBC, WBC, hemoglobin, hematocrit, MCV, serum creatinine, urinary creatinine, urinary microalbumin) associated with exposure factors (geographical quadrants and distance from the Feed Materials Production Center (FMPC); well or cistern drinking water source) when compared with NANES data (NHANES=7,312, FMMP=8,464). The FMMP cohort consisted of persons 18 years or older who resided within a 5-mile radius of the FMPC for a 2-year minimum period between January, 1952, to December, 1984, excluding FMPC workers. Results: Because of concerns regarding methodologic bias in comparing FMMP to NHANES, the data analysis focused on inter-FMMP comparisons. Hematocrit was increased in participants who ever used well or cistern drinking water (n=5,379) versus those who never (n=3,058) by 1.86% (0.56-3.18% confidence interval of 99.9%); Red blood cells were increased by 1.65% (0.35-2.97). Among participants who ever lived within 2 miles (n=3,507) in relation to participants 3-5 miles of the FMPC, white blood cells were increased by 10.54% (5.54-15.76) (without drinking water source in the model). When only FMMP participants who had ever used well or cistern drinking water were selected (n=5,404), persons who had ever used well or cistern drinking water from a source within 2 miles (n=2,383) from the FMPC had an increase in total white blood cells of 8.52% (2.44-14.95) versus those who had only used well or cisterns within 3-5 miles (n=3,021) from the FMPC. Conclusion: Further epidemiological research should consider distance from the FMPC and use of well or cistern water as potential risk factors; and should follow-up on potential increases in hematocrit, red blood cells, and white blood cell counts.
Susan Pinney (Advisor)
Hematocrit; Fernald; FMMP; FMPC; NHANES; RBC; Residents; WBC

Recommended Citations

Citations

  • Brannen, D. E. (2000). Comparison of Selected Clinical Laboratory Tests on Adult Participants of the Fernald Medical Monitoring Program (FMMP), from the First Medical Examination from 1991 to 1994, Using the Third National Health and Nutrition Examination Survey (NHANES III) co [Master's thesis, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin976116589

    APA Style (7th edition)

  • Brannen, Donald. Comparison of Selected Clinical Laboratory Tests on Adult Participants of the Fernald Medical Monitoring Program (FMMP), from the First Medical Examination from 1991 to 1994, Using the Third National Health and Nutrition Examination Survey (NHANES III) co. 2000. University of Cincinnati, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin976116589.

    MLA Style (8th edition)

  • Brannen, Donald. "Comparison of Selected Clinical Laboratory Tests on Adult Participants of the Fernald Medical Monitoring Program (FMMP), from the First Medical Examination from 1991 to 1994, Using the Third National Health and Nutrition Examination Survey (NHANES III) co." Master's thesis, University of Cincinnati, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=ucin976116589

    Chicago Manual of Style (17th edition)

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