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ENDOCRINE DISRUPTION RELATED TO FUEL EXPOSURE AMONGST WOMEN IN THE MILITARY AND RACIAL DIFFERENCES IN ENDOCRINE LEVELS

Reutman, Susan Simpson
http://rave.ohiolink.edu/etdc/view?acc_num=ucin985628877

Abstract Details

2001, PhD, University of Cincinnati, Medicine : Environmental Health Sciences.
Introduction: Hydrocarbons (HCs) found in fuels and solvents are ubiquitous in the environment, yet little is known about their endocrine effects. The primary study objective was to assess reproductive endocrine effects of low-dose fuel and solvent exposure encountered by reproductive aged female US Air Force (USAF) personnel. Further, few studies have evaluated whether reproductive hormone ranges that are normal for Caucasians are applicable as norms for other races. Hence, the second objective was to compare reproductive hormone levels between African American and Caucasian USAF women. Methods: Endocrine markers associated with conceptive menstrual cycles (higher preovulatory luteinizing hormone [LH], mid-luteal phase pregnanediol 3-glucuronide [Pd3G], mid-luteal phase estrone 3-glucuronide [E 1 3G], and lower follicular phase [Pd3G]) were measured in daily urine samples and used as endpoints for the primary analysis. Exhaled breath levels of HCs in fuels and solvents were measured and included total aliphatic (C 6 H 1414 -C 16 H 34 ), and total aromatic (benzene, ethyl-benzene, toluene, and m,p,o-xylenes) HCs. Reproductive and exposure information was also obtained from baseline questionnaires and daily diaries. Endpoints for the race analysis included creatinine-adjusted urinary LH, Pd3G, E 1 3G, and follicle stimulating hormone (FSH) concentrations. Effects of fuel exposure and racial differences were analyzed separately using regression analysis with models including potential confounders and covariates. Results: Regression analyses revealed that preovulatory LH levels were significantly (β =-7.34; p=0.007) lower among women whose total aliphatic HCs levels were in the high exposure group. Also, relative to Caucasians, African American women had lower follicular phase LH:FSH ratios (β =-0.23, p=0.03), follicular phase Pd3G levels (β =-0.33, p=0.05), and slope of periovulatory Pd3G (β =-0.48, p=0.02). Conclusions: The relationship between aliphatic HCs and lowered preovulatory LH levels suggests compounds in fuels and some solvents may alter hormone levels. Racial differences were found for three hormonal endpoints. Future studies to confirm these findings are indicated.
Grace Lemasters (Advisor)
endocrine; reproductive hormones; fuels; solvents; racial differences

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Citations

  • Reutman, S. S. (2001). ENDOCRINE DISRUPTION RELATED TO FUEL EXPOSURE AMONGST WOMEN IN THE MILITARY AND RACIAL DIFFERENCES IN ENDOCRINE LEVELS [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin985628877

    APA Style (7th edition)

  • Reutman, Susan. ENDOCRINE DISRUPTION RELATED TO FUEL EXPOSURE AMONGST WOMEN IN THE MILITARY AND RACIAL DIFFERENCES IN ENDOCRINE LEVELS. 2001. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin985628877.

    MLA Style (8th edition)

  • Reutman, Susan. "ENDOCRINE DISRUPTION RELATED TO FUEL EXPOSURE AMONGST WOMEN IN THE MILITARY AND RACIAL DIFFERENCES IN ENDOCRINE LEVELS." Doctoral dissertation, University of Cincinnati, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin985628877

    Chicago Manual of Style (17th edition)

ucin985628877
© 2001, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.