Skip to Main Content
 

Global Search Box

 
 
 
 

Files

File List

Full text of this paper is not available in the ETD Center. Copies may be available for inter-library loan from University of Cincinnati or may be available for purchase from Proquest/UMI

ETD Abstract Container

Abstract Header

THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLES

Duis, Christine Ann
http://rave.ohiolink.edu/etdc/view?acc_num=ucin990818739

Abstract Details

2001, PhD, University of Cincinnati, Arts and Sciences : Psychology.
Accumulating evidence suggests that Bipolar Disorder (BPD) is associated with cognitive impairment, but there are inconsistencies in the literature as to the nature, degree, and pattern of impairment. This study was undertaken, in part, to address prior methodological limitations by providing quantitative assessment of mood state at time of assessment, employing strict diagnostic criteria for subject inclusion, controlling for substance abuse and medication variables, and utilizing a comprehensive battery of neuropsychological measures to allow for the analysis of specific deficits within the broader neurocognitive profile. BPD participants were assessed during the manic and mixed phase of the illness, which to date have received little attention, to allow for better characterization of cognitive functioning during these mood states. Based on accumulating evidence of the link between subcortical brain abnormalities and cognitive deficits in BPD, the present study examined whether BPD participants produced neuropsychological profiles that were more characteristic of subcortical than of cortical brain dysfunction. The link between neurocognition and etiologic factors was examined by elucidating the relationship between disease course, symptom severity, and neurocognitive impairment. The results indicate that this sample of BPD participants demonstrate deficits in attention, new learning, and problem solving ability but perform normally on tasks of confrontation naming, receptive language, sensory-perception, visuoperception, speeded processing, and mental set shifting. These findings provide support for accumulating evidence which suggests the presence of a specific pattern of cognitive sparing and impairment during the manic or mixed mood state. The results provide very tentative support for the subcortical dysfunction hypothesis. Although the BPD sample's pattern of performance was similar to that of individuals with known subcortical brain dysfunction, the group did not differ from controls on composite summary z-scores which were comprised of measures that have been shown to be differentially sensitive to subcortical versus cortical disease. Finally, this study provides no evidence that these deficits worsen with disease progression or recurrence of affective episodes or are related to the severity of mood symptoms, with the exception of poorer attentional ability in individuals with more depressive symptoms.
Paula Shear (Advisor)
NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER

Recommended Citations

Citations

  • Duis, C. A. (2001). THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLES [Doctoral dissertation, University of Cincinnati]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990818739

    APA Style (7th edition)

  • Duis, Christine. THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLES. 2001. University of Cincinnati, Doctoral dissertation. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=ucin990818739.

    MLA Style (8th edition)

  • Duis, Christine. "THE NEUROPSYCHOLOGICAL FUNCTIONING OF BIPOLAR DISORDER DURING MANIA AND RELATIONSHIP TO DEMOGRAPHIC AND DISEASE VARIABLES." Doctoral dissertation, University of Cincinnati, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990818739

    Chicago Manual of Style (17th edition)

ucin990818739
© 2001, all rights reserved.
This open access ETD is published by University of Cincinnati and OhioLINK.