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Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients

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2008, Master of Science (MS), Wright State University, Microbiology and Immunology.
Eosinophils express membrane CD4 protein and can bind HIV-1 glycoprotein (gp) 120. Therefore, eosinophils could serve as host cells for HIV-1 infection in vivo, especially in the late phase of the infection. In culture, HIV-1 infects eosinophil precursors and primary eosinophils. Additionally HIV-1 proviral DNA sequences have been detected in the eosinophils of some HIV-1 positive patients. Since elevated levels of eosinophils occur during HIV-1 infection and parasitic infections, it implies that co-infection of parasites and HIV-1 could cause a much greater increase in the level of potential HIV-1 susceptible eosinophils. Therefore HIV-1 infection of eosinophils could partly explain the rapid spread of HIV-1 and the exacerbation of the disease especially in developing countries where HIV-1 and parasitic infections run concurrently. This study is a critical analysis of the current knowledge on HIV-1 infection of eosinophils focused on highlighting evidence that HIV-1 can productively infect mature human eosinophils in HIV/AIDS patients.
Dawn Wooley, Ph.D (Advisor)
Barbara Hull, Ph.D (Committee Member)
Nancy Bigley, Ph.D (Committee Member)
54 p.

Recommended Citations

Citations

  • Atem, J. N. (2008). Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964

    APA Style (7th edition)

  • Atem, Jude. Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients. 2008. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964.

    MLA Style (8th edition)

  • Atem, Jude. "Human Immunodeficiency Virus-1 Productively Infects Mature Terminally Differentiated Eosinophils in HIV/AIDS Patients." Master's thesis, Wright State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1208724964

    Chicago Manual of Style (17th edition)