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Effects of Subcutaneous Postnatal Choline Supplementation on Hippocampus-Mediated Learning and Memory in Rat Pups

Moore, Jeremy Alan
http://rave.ohiolink.edu/etdc/view?acc_num=wright1213369647

Abstract Details

2008, Master of Science (MS), Wright State University, Anatomy.
The effects of postnatal injections of choline on the acquisition of two variants of eyeblink conditioning were examined in developing Long-Evans rat pups. Choline administration on postnatal days (PND) 15-27 was followed by evaluation of trace eyeblink conditioning (Experiment 1) and delay eyeblink conditioning (Experiment 2) on PND 28-29. The results of these experiments show that choline produced greater improvements in learning and memory during the trace condition than in the delay condition, presumably due to its effect on the hippocampus. Trace eyeblink conditioning relies heavily on an intact hippocampus but delay eyeblink conditioning does not, and it is understood that choline has a positive influence on hippocampal function. This was the first study to examine the effects of choline on eyeblink conditioning and provides baseline data for future research into the beneficial effects of choline for this type of learning as well as its potential neuroprotective effects for the hippocampus.
Dragana Claflin, Ph.D. (Advisor)
Larry Ream, Ph.D. (Committee Member)
Michael Hennessey, Ph.D. (Committee Member)
Joseph Thomas, Ph.D. (Other)
Timothy Cope, Ph.D. (Committee Chair)
46 p.
Psychology
choline; hippocampus; trace conditioning; eyeblink conditioning; learning

Recommended Citations

Citations

  • Moore, J. A. (2008). Effects of Subcutaneous Postnatal Choline Supplementation on Hippocampus-Mediated Learning and Memory in Rat Pups [Master's thesis, Wright State University]. OhioLINK Electronic Theses and Dissertations Center. http://rave.ohiolink.edu/etdc/view?acc_num=wright1213369647

    APA Style (7th edition)

  • Moore, Jeremy. Effects of Subcutaneous Postnatal Choline Supplementation on Hippocampus-Mediated Learning and Memory in Rat Pups. 2008. Wright State University, Master's thesis. OhioLINK Electronic Theses and Dissertations Center, http://rave.ohiolink.edu/etdc/view?acc_num=wright1213369647.

    MLA Style (8th edition)

  • Moore, Jeremy. "Effects of Subcutaneous Postnatal Choline Supplementation on Hippocampus-Mediated Learning and Memory in Rat Pups." Master's thesis, Wright State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1213369647

    Chicago Manual of Style (17th edition)

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© 2008, all rights reserved.
This open access ETD is published by Wright State University and OhioLINK.